About Terry Beerman
Positions
Roswell Park Comprehensive Cancer Center
- Department of Pharmacology and Therapeutics
Research
Research Overview:
Cellular response to enediyne induced DNA double strand breaks
Cellular response to drug induced stalling of DNA replication
Publications
- Beerman TA, Gawron LS, Shin S, Shen B, McHugh MM. C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells. Cancer Res. 2009 Jan 15;69(2):593-8. doi: 10.1158/0008-5472.CAN-08-2753. PMID: 19147573; PMCID: PMC2758494.
- McHugh MM, Beerman TA. An extraction-free method by which a single slot blot can be used to quantify intracellular DNA damage (crosslinks or strand breaks) and changes in DNA damage response proteins or replication. Biotechniques. 2009 Feb;46(2):127-9. doi: 10.2144/000113046. PMID: 19317657.
- Kennedy DR, Gawron LS, Ju J, Liu W, Shen B, Beerman TA. Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. Cancer Res. 2007 Jan 15;67(2):773-81. doi: 10.1158/0008-5472.CAN-06-2893. PMID: 17234789.
- Kennedy DR, Ju J, Shen B, Beerman TA. Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17632-7. doi: 10.1073/pnas.0708274104. Epub 2007 Oct 31. PMID: 17978180; PMCID: PMC2077023.
- San Pedro JM, Beerman TA, Greenberg MM. DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases. Bioorg Med Chem. 2012 Aug 1;20(15):4744-50. doi: 10.1016/j.bmc.2012.06.004. Epub 2012 Jun 9. PMID: 22748380; PMCID: PMC3406177.