Dr. Song Yao received his PhD in molecular epidemiology from RPCI in 2009, and continued his cancer research work at RPCI as a postdoctoral fellow afterwards. In 2012, he was appointed to a faculty position as an Assistant Member in the Department of Cancer Prevention and Control, and in 2014, promoted to Associate Member. Dr. Yao’s research interests are using epidemiological tools to understand molecular and genetic mechanisms of cancer etiology, progression, health disparities, prognosis, and treatment prediction, and discovering and developing cancer biomarkers with potential clinical utility.
Using multidisciplinary tools from epidemiology, biostatistics, genetics, epigenetics and clinical oncology, Dr. Yao studies molecular and genetic factors related to cancer occurrence, progression, prognosis, response to treatment, as well as health disparities.
He leads a number of active research projects based on several outstanding study populations, including the Women’s Circle of Health Study (WCHS), the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium, and the Pathways Study. He plays an integral role in each of those regional or national population studies. He is also an active member in the SWOG cooperative group. Dr. Yao is a multi-PI of an NCI funded R01 project of bone health in postmenopausal breast cancer patients treated with aromatase inhibitors based on the Pathways Study, and is the PI of a Susan G. Komen Foundation funded project of noncoding RNAs in breast cancer treatment outcomes based on a SWOG clinical trial. In addition, Dr. Yao is also developing a number of pilot studies to explore novel biomarkers, both germline and somatic genetic and epigenetic markers, for cancer diagnosis, prognosis and prediction, based on RPCI’s Data Bank and Biorepository (DBBR) resource.
He leads a fully-equipped wet laboratory capable of performing various assays and procedures suitable for population studies. As the long-term overarching goal, Dr. Yao is particularly enthusiastic in translational research to apply scientific findings to cancer patients for better prevention, treatment and survivorship.
Yao S, Smiley SL, West K, Lamonica D, Battiwalla M, McCarthy PL, Hahn T.Accelerated bone mineral density loss occurs with similar incidence and severity, but with different risk factors, after autologous versus allogeneic hematopoietic cell transplantation. Biology of blood and marrow transplantation2010; 16(8):1130-1137
Yao S , Hayes DF , Hortobagyi GN , Abeloff MD , Kent Osborne C , Lyss AP , Martino S , Ravdin PM , Hutchins LF , Yeh I-T , Rae JM , Davis W , Livingston RB , Zhao H , Choi J-Y , Albain KS , Barlow WE , Ambrosone CB. Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Breast cancer research and treatment 2010; 124(2):433-439
Yao S , Hayes DF , Hortobagyi GN , Abeloff M , Osborne CK , Lyss AP , Martino S , Ravdin PM , Hutchins LF , Yeh I-T , Rae JM , Davis W , Livingston RB , Zhao H , Choi J-Y , Albain KS , Barlow WE , Ambrosone CB. Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer.Clinical cancer research 2010; 16(24):6169-6176
Ambrosone CB, Sucheston L, Demissie K, Amend KL, Tartter P, Reilly J, Pace BW, Rohan T, Sparano J, Raptis G, Castaldi M, Estabrook A, Feldman S, Weltz C, Roberts M, Davis W, Ciupak GL, Bandera EV, Jandorf L, Bovbjerg DH, Zirpoli G, Pawlish K, Godbold J, Furberg H, Fatone A, Valdimarsdottir H,Yao S, Li Y, Hwang H, Kemeny M. Conducting Molecular Epidemiological Research in the Age of HIPAA: A Multi-Institutional Case-Control Study of Breast Cancer in African-American and European-American Women. Journal of oncology 2009; 2009:871250
Hahn T, Yao S, Dunford LM, Thomas J, Lohr J, Arora P, Battiwalla M, Smiley SL, McCarthy Jr PL. A comparison of measured creatinine clearance versus calculated glomerular filtration rate for assessment of renal function before autologous and allogeneic BMT. Biology of blood and marrow transplantation2009; 15(5):574-579
Yao S, O'Connor TL, Edge SB, Kulkarni S, Hwang H, McCann SE, Hong C-C, Davis W, Nesline MK, Trump DL, Johnson CS, Millen AE, Sucheston LE, Ambrosone CB. Pretreatment serum concentrations of 25-hydroxyvitamin d and breast cancer prognostic characteristics: a case-control and a case-series study. PloS one 2011; 6(2):e17251
Yao S, Padmanabhan S, Battiwalla M, Smiley S, Lamonica D, Syta M, Paplham P, Brown K, Roy DM, Dunford LM, McCarthy PL, Hahn T. High prevalence of early-onset osteopenia/osteoporosis after allogeneic stem cell transplantation and improvement after bisphosphonate therapy. Bone marrow transplantation2008; 41(4):393-398
Ambrosone CB, Kropp S, Yang J, Yao S, Shields PG, Chang-Claude J.Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. Cancer epidemiology, biomarkers and prevention 2008; 17(1):15-26
Tang L, Thompson IM, Lippman SM, Hoque A, Hsing A, Santella RM, Reichardt JK, Stanczyk FZ, Neuhouser ML, Platz EA, Kristal AR, Wu Y, Tangen CM, Goodman PJ, Till C, Yao S, Ambrosone CB. Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Carcinogenesis 2011; 32(10):1500-1506
Yao S, Ambrosone CB, Thompson IM, Lippman SM, Parnes HL, Price DK, Figg WD, Santella RM, Neuhouser ML, Tang L, Reichardt JK, Stanczyk FZ, Platz EA, Tangen CM, Hsing AW, Goodman PJ, Kristal AR, Till C, Hoque A. Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case-control study. Cancer causes and control : CCC 2011;22(8):1121-1131
Ambrosone CB, Sucheston LE, Zhao H, Yao S, Budd GT, Barlow WE, Hershman DL, Davis W, Ciupak C, Stewart JA, Isaacs C, Hobday T, Latreille J, Hortobagyi GN, Gralow JR, Livingston R, Albain KS, Hayes DF. Variants in the BRCA1/Fanconi-Anemia Repair Pathway and Taxane-Induced Neuropathy in SWOG S0221. Cancer research 2009; 69(24 Suppl. 3):592S
Hahn T, Yao S, Smiley S, West K, Battiwalla M, Lamonica D, McCarthy PL.Clinical and Genetic Factors Underlying Acute Bone Mineral Density Loss by 100 Days after Blood and Marrow Transplantation: A Potential Early Regimen-Related Complication. Blood 2008; 112(11):26-27
Sucheston LE, Zhao H, Yao S, Zirpoli G, Liu S, Barlow WE, Moore HCF, Thomas Budd G, Hershman DL, Davis W, Ciupak GL, Stewart JA, Isaacs C, Hobday TJ, Salim M, Hortobagyi GN, Gralow JR, Livingston RB, Albain KS, Hayes DF, Ambrosone CB. Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221).Breast cancer research and treatment 2011; 130(3):993-1002
Yao S, Sucheston LE, Smiley SL, Davis W, Conroy JM, Nowak NJ, Ambrosone CB, McCarthy PL Jr, Hahn T. Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation.PloS one 2011; 6(10):e25940
Roberts M, Hong C-C, Edge S, Yao S, Nesline M, Ambrosone CB.Polymorphisms in metastasis suppressor genes (BRMS1 and SIPA1): Breast tumor characteristics and lymph node metastasis. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #5595
Yao S, Zirpoli G, Hong C-C, Tang L, Zhao H, Sucheston L, Shankar J, Roberts M, Ruszczyk M, Ciupak G, Davis W, Hwang H, McCann S, Bandera E, Ambrosone C. Common genetic variations in VDR, CYP27B1 and CYP24A1 genes and breast cancer risk in African American and European American women in the Women’s Circle of Health Study. Proceedings of the American Association for Cancer Research Annual Meeting 2011; 52:Abstract #5603
Yao S, Zirpoli G, Bovbjerg DH, Jandorf L, Hong CC, Zhao H, Sucheston LE, Tang L, Roberts M, Ciupak G, Davis W, Hwang H, Johnson CS, Trump DL, McCann SE, Ademuyiwa F, Pawlish KS, Bandera EV, Ambrosone CB. Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study.Breast cancer research : BCR 2012; 14(2):R58