Research Interests:
Understanding the genetic fingerprint of metastatic disease Animal models for study of cancer and metastasis (mouse/woodchuck) Pancreatic neuroEndocrine disease-Development and investigation of a novel mouse model to study cancer progression from primary disease through circulating tumor cell (CTC) involvement to metastasis Advanced genomic technologies for the study of cancer: Next-Generation Sequencing (NGS) including single-cell sequencing for study of CTCs Development of novel clinical approaches to identify actionable mutations from bio-fluids (CTCs, cfDNA/RNA) for diagnosis, prognosis, and treatmentAbout Sean Glenn
Biography:
I received a Bachelor’s of Science in Biology from the State University of New York at Buffalo where I studied the RIP function in Neurospora crassa which is a duplication and mutation event localized to the premeiotic cells of the life cycle. I then went on to earn a Master’s of Science from the University at Buffalo focusing on transcriptional regulation of genes responsible for vascular development.
Furthermore, I received a PhD in Molecular and Cellular Biology from the Roswell Park Comprehensive Cancer Center Division of the University of Buffalo where, in the laboratory of Dr. Kenneth W. Gross, I developed a mouse model that mimics human metastatic pancreatic neuroendocrine carcinoma. This model, coupled with NGS technology, is a powerful tool for studying the cooperating mutations responsible for the evolution of metastatic disease including the identification and the role circulating tumor cells play in the progression of this process. This model also offers great promise for studying the pharmaceutical intervention of the metastatic phenotype.
With an interest in advanced genomic technologies and tumor mutation profiling I began my training in Molecular Pathology receiving a Certificate of Qualification from the NYS DOH. This clinical accreditation affords me the opportunity to act as director of the clinical Advanced Molecular Diagnostic Laboratory as well as submit cutting-edge clinical assays to the NYS CLEP program for use as diagnostic, prognostic and therapeutic testing for our patients. Leveraging my experience using stare-of-the-art genomics technologies along with my clinical responsibilities as lab director and Vice-Chair I drive strategic partnerships and commercialization of intellectual property developed at Roswell Park for use throughout the country and world, maintain Roswell on the forefront of innovation in the field of oncology.
Positions
- Associate Professor of Oncology
- Clinical Director, Genomics Shared Resource
- Vice Chair, Molecular Pathology
- Director, Advanced Molecular Diagnostics Laboratory
- Department of Pathology and
Background
Education and Training:
- 2014 - PhD - Molecular and Cellular Biology – State University of New York at Buffalo, Buffalo, NY
- 2002 - MS - Natural Sciences - State University of New York at Buffalo, Buffalo, NY
Publications
- Pippin JW, Kaverina NV, Eng DG, Krofft RD, Glenn ST, Duffield JS, Gross KW, Shankland SJ. Cells of renin lineage are adult pluripotent progenitors in experimental glomerular disease. Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F341-58. doi: 10.1152/ajprenal.00438.2014. Epub 2015 Jun 10. PMID: 26062877
- Zhu Q, Hu Q, Shepherd L, Wang J, Wei L, Morrison CD, Conroy JM, Glenn ST, Davis W, Kwan ML, Ergas IJ, Roh JM, Kushi LH, Ambrosone CB, Liu S, Yao S. The Impact of DNA Input Amount and DNA Source on the Performance of Whole-Exome Sequencing in Cancer Epidemiology.Cancer Epidemiol Biomarkers Prev. 2015 Aug;24(8):1207-13. doi: 10.1158/1055-9965.EPI-15-0205. Epub 2015 May 19. PMID: 25990554
- Glenn ST, Jones CA, Sexton S, LeVea CM, Caraker SM, Hajduczok G, Gross KW. Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma. Oncogene. 2014 Dec 11;33(50):5706-15. PubMed PMID: 24292676; PubMed Central PMCID: PMC4041964.
- Morrison CD, Liu P, Woloszynska-Read A, Zhang J, Luo W, Qin M, Bshara W, Conroy JM, Sabatini L, Vedell P, Xiong D, Liu S, Wang J, Shen H, Li Y, Omilian AR, Hill A, Head K, Guru K, Kunnev D, Leach R, Eng KH, Darlak C, Hoeflich C, Veeranki S, Glenn S, You M, Pruitt SC, Johnson CS, Trump DL. Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E672-81. PubMed PMID: 24469795; PubMed Central PMCID: PMC3926024.
- Glenn ST, Jones CA, Gross KW, Pan L. Control of renin [corrected] gene expression. Pflugers Arch. 2013 Jan;465(1):13-21. PubMed PMID: 22576577; PubMed Central PMCID: PMC4370267.