Research Interests:
RNA editing microRNAs cancer biology oncoimmunology bioinformatics biomarkers blood group antigensAbout Santosh Patnaik
Biography:
Dr. Santosh K. Patnaik joined the staff of the Department of Thoracic Surgery of Roswell Park Comprehensive Cancer Center as an Assistant Professor in 2011. He has been a principal investigator or co-investigator for multiple research projects that have recently been funded by the National Institutes of Health (NIH), the US Department of Defense, and the CHEST Foundation of the American College of Chest Physicians. Dr. Patnaik has served as a grant application reviewer for the NIH and the Alliance Research Foundation, and is an editorial board member for the PeerJ, PLOS ONE, and Scientific Reports journals. He is also a co-founder and curator of the Blood Group Antigen Gene Mutation Database of NCBI, NIH.
Positions
- Assistant Professor of Oncology, Department of Thoracic Surgery
- Assistant Member, Department of Thoracic Surgery
Jacobs School Of Medicine And Biomedical Sciences, State University of New York at Buffalo
- Clinical Assistant Professor
- Department of Surgery
Background
Education and Training:
- 2004 - PhD - Albert Einstein College of Medicine, New York, NY
- 2000 - MS - Albert Einstein College of Medicine, New York, NY
- 1997 - MD - All India Institute of Medical Sciences, New Delhi, India
Research
Research Overview:
The focus of my research group has lately been on the following:
RNA editing: We discovered very specific C-to-U RNA editing for scores of genes that occurs in macrophages during their M1 (pro-inflammatory) but not M2 polarization, and identified APOBEC3A cytidine deaminase as the enzyme that causes this editing. We subsequently identified RNA editing activity of some other APOBEC proteins. Examination of the prevalence, enzymatic basis, and regulation of RNA editing; relevance of RNA editing in cancer and immunology; and, development of tools to study and to utilize the phenomenon of RNA editing form a large part of our research interest.
Tumor microenvironment: Through the utilization and integration of high-throughput data, we characterize various aspects of the tumor microenvironment for a variety of cancers. While the facets are diverse (microbiome, lymphatic invasion, etc.), the overarching desire has been to obtain insights on biological as well as biomarker values in cancer.
MicroRNAs: We are interested in the biology as well as biomarker utility of tissue and circulating microRNAs, especially in context of cancer. We are also interested in the development of new tools for microRNA assays.
Publications
1. Patnaik SK, Petrucci C, Barbi K, Seager R, Pabla S, and Yendamuri S. Obesity-specific association of statin use and reduce risk of recurrence of early stage NSCLC. Journal of Thoracic Oncology Clinical and Research Reports, 2(12):100254, 2021
2. Asaoka M, Patnaik SK, Ishikawa T, and Takabe K. Different members of the APOBEC3 family of DNA mutators have opposing associations with the landscape of breast cancer. American Journal of Cancer Research, 11(10):5111-25, 2021
3. Barbi K, Patnaik SK, Pabla S, Zollo R, Smith RJ, Sass SS, Srinivasan A, Petrucci C, Seager R, Conroy J, Kannisto E, Wang X, Shah S, Gosain R, Attwood K, Roche C, and Yendamuri S. Visceral obesity promotes lung cancer progression – Toward resolution of the obesity paradox in lung cancer. Journal of Thoracic Oncology, 16(8):1333-48, 2021
4. Yang Y, Kannisto E, Yu G, Patnaik SK, Reid M, Li L, and Wu Y. Ultrafast detection of exosomal RNAs via cationic lipoplex nanoparticles in a micromixer biochip for cancer diagnosis. ACS Applied Nano Materials, 4(3):2806-19, 2021
5. Patnaik SK, Cortes EG, Punnanitinont A, Dhillon SS, Liu S, and Yendamuri S. Lower airway bacterial microbiome may influence recurrence after resection of early-stage non-small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery, 161(2): 419-29, 2020