Dr. Santosh K. Patnaik joined the staff of the Department of Thoracic Surgery of Roswell Park Comprehensive Cancer Center as an Assistant Professor in 2011. He has been a principal investigator or co-investigator for multiple research projects that have recently been funded by the National Institutes of Health (NIH), the US Department of Defense, and the CHEST Foundation of the American College of Chest Physicians. Dr. Patnaik has served as a grant application reviewer for the NIH and the Alliance Research Foundation, and is an editorial board member for the PeerJ, PLOS ONE, and Scientific Reports journals. He is also a co-founder and curator of the Blood Group Antigen Gene Mutation Database of NCBI, NIH.
The focus of my research group has lately been on the following:
1. RNA editing: We discovered very specific C-to-U RNA editing for scores of genes that occurs in macrophages during their M1 (pro-inflammatory) but not M2 polarization, and identified APOBEC3A cytidine deaminase as the enzyme that causes this editing. We subsequently identified RNA editing activity of some other APOBEC proteins. Examination of the prevalence, enzymatic basis, and regulation of RNA editing; relevance of RNA editing in cancer and immunology; and, development of tools to study and to utilize the phenomenon of RNA editing form a large part of our research interest.
2. MicroRNAs: Our recent work has been on the biology as well as biomarker utility of tissue and circulating microRNAs that are associated with specific histotypes of lung cancer, recurrence of early-stage lung cancer after its surgical resection, progression of intra-epithelial neoplasia to prostate cancer, and childhood obesity/hypertension. We are also interested in the development of new tools for microRNA assays.
Selected Recent Publications
* co-first author; # corresponding author
- Sharma S, Patnaik SK, Kemer Z, Baysal BE. The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme. Scientific Reports. 2016. 6:39100.
- Sharma S, Patnaik SK*#, Kemer Z, and Baysal BE. Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes. RNA Biology. 2016. In press.
- Mallick R, Patnaik SK, Wani S, and Bansal A. A systematic review of esophageal microRNA markers for diagnosis and monitoring of Barrett's esophagus. Digestive Diseases and Sciences. 2016. 61(4):1039-50.
- Sharma S, Patnaik SK*, Taggart RT, Kannisto E, Enriquez SM, Gollnick P, and Baysal BE. APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages. Nature Communications. 2015. 6:6881.
- Buitrago D, Patnaik SK*, Kadota K, Kannisto E, Jones D, and Adusumilli PS. Small RNA sequencing for profiling microRNAs in long-term preserved formalin-fixed and paraffin-embedded non-small cell lung cancer tumor samples. PLOS ONE. 2015. 10(3):e0121521.
- Patnaik SK, Mallick R, Kannisto E, Bshara W, Yendamuri S, and Dhillon SS. miR-205 and miR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. Journal of Thoracic Oncology. 2015. 10(3):446-53.
- Patnaik SK, Helmberg W, and Blumenfeld OO. BGMUT database of allelic variants of genes encoding human blood group antigens. Transfusion Medicine and Hemotherapy. 2014. 41(5):346-51.
- Baysal BE, De Jong K, Liu B, Wang J, Patnaik SK, Wallace PK, and Taggart RT. Hypoxia-inducible C-to-U coding RNA editing downregulates SDHB in monocytes. PeerJ. 2013. 1:e152.
- Patnaik SK, Yendamuri S, Kannisto E, Kucharczuk J, Singhal S, and Vachani A. MicroRNA expression profiles of whole blood in lung adenocarcinoma. PLOS ONE. 2012. 7(9):e46045.
Last updated on April 23, 2015