About Qiang Hu
Biography:
Dr. Hu joined the Roswell Park faculty in 2010. He graduated from Peking University with a degree in medicine and received his PhD in Bioinformatics from Tsinghua University. He is skilled in PERL and R computing languages, and has extensive experience in utilizing parallel computing in high-performance servers to process, analyze and interpret high-dimension, high-complexity data. An example of a recently developed tool is VPA (Hu et al. BMC Research Note. 2012; 5:31 PMC3293055), which is a customized package for analyzing variants with user-specified frequency pattern from NGS studies.
Positions
Roswell Park Comprehensive Cancer Center
- Senior Bioinformatician
Background
Education and Training:
- PhD - Bioinformatics, Tsinghua University
- MD - Peking University
Publications
- Yasumizu Y, Rajabi H, Jin C, Hata T, Pitroda S, Long MD, Hagiwara M, Li W, Hu Q, Liu S, Yamashita N, Fushimi A, Kui L, Samur M, Yamamoto M, Zhang Y, Zhang N, Hong D, Maeda T, Kosaka T, Wong KK, Oya M, Kufe D. MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun. 2020 Jan 17;11(1):338. doi: 10.1038/s41467-019-14219-6. Erratum in: Nat Commun. 2020 Feb 24;11(1):1095. PMID: 31953400; PMCID: PMC6969104.
- Zhu Q, Zhang J, Chen Y, Hu Q, Shen H, Huang RY, Liu Q, Kaur J, Long M, Battaglia S, Eng KH, Lele SB, Zsiros E, Villella J, Lugade A, Yao S, Liu S, Moysich K, Odunsi KO. Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes. Int J Cancer. 2020 Apr 15;146(8):2147-2155. doi: 10.1002/ijc.32545. Epub 2019 Jul 16. PMID: 31265121; PMCID: PMC7065147.
- Phillips JW, Pan Y, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D, Hu Q, Liu S, Black DL, Witte ON, Xing Y. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5269-5279. doi: 10.1073/pnas.1915975117. Epub 2020 Feb 21. PMID: 32086391; PMCID: PMC7071906.
- Li W, Zhang N, Jin C, Long MD, Rajabi H, Yasumizu Y, Fushimi A, Yamashita N, Hagiwara M, Zheng R, Wang J, Kui L, Singh H, Kharbanda S, Hu Q, Liu S, Kufe D. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020 Jun 18;5(12):e137112. doi: 10.1172/jci.insight.137112. PMID: 32427590; PMCID: PMC7406273.
- Zhang D, Hu Q, Liu X, Ji Y, Chao HP, Liu Y, Tracz A, Kirk J, Buonamici S, Zhu P, Wang J, Liu S, Tang DG. Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer. Nat Commun. 2020 Apr 29;11(1):2089. doi: 10.1038/s41467-020-15815-7. PMID: 32350277; PMCID: PMC7190674.