Specializing In:
- Pathology
- Flow Cytometry
Research Interests:
- Clinical diagnosis and monitoring of leukemia, myelodysplastic syndromes and lymphoma by flow cytometry
- Application of flow cytometry to monitoring immune cell function
- Immunotherapy of cancer with differentiated myeloid cells
Biography
Served from 2003-2021 as Director of the Flow and Image Cytometry Department at Roswell Park Comprehensive Cancer Center in Buffalo, NY. Currently a Professor Emeritus at Roswell Park and the Chief Scientific Officer at SciGro, Inc. SciGro is a partnership supporting the translation of research and preclinical stage technology into products for the biomedical industries. Past President of the International Society for Advancement of Cytometry an organization with over 2,000 members, active in the International Clinical Cytometry Society, Associate Editor of Clinical Cytometry, and the 2018 recipient of ICCS’s Wallace H. Coulter award for lifetime achievement in clinical cytometry.
Before joining Roswell Park, Dr. Wallace was an Assistant Professor of Immunology at Dartmouth Medical School, Hanover NH (1993-2003), a cofounder of Zynaxis Cell Science, Inc., Malvern PA (1988-1991), and the Supervisor of Flow Cytometry at SmithKline (now Quest) Clinical Laboratories King of Prussia, PA (SKCL; 1979-1988).
Positions
Roswell Park Comprehensive Cancer Center
- Professor Emeritus of Oncology
- Director, Department of Flow & Image Cytometry
State University of New York at Buffalo
- Associate Professor of Pathology
Background
Education and Training
- 1989-1993 - PhD - Department of Microbiology & Immunology, Medical College of Pennsylvania, Philadelphia, PA
- 1976-1979 - MS - Department of Microbiology and Biochemistry, Idaho State University, Pocatello, ID
Residency
- 2003-Present - Adjunct Associate Professor, Norris Cotton Cancer Center, Dept. of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH
- 1997-2003 - Research Assistant Professor, Norris Cotton Cancer Center, Dept. of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH
Fellowship
- 1994-1997 - Post-Doctoral Fellow - Norris Cotton Cancer Center, Dept. of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH
Professional Memberships
- International Society for Analytical Cytometry
- International Clinical Cytometry Society
- Great Lakes International Imaging and Flow Cytometry Association
Publications
Soh KT, Came N, Otteson GE, Jevremovic D, Shi M, Olteanu H, Natoni A, Lagoo A, Theakston E, Óskarsson JÞ, Gorniak M, Grigoriadis G, Arroz M, Fletcher M, Lin P, Ludwig P, Tembhare P, Matuzeviciene R, Radzevicius M, Kay S, Chen W, Cabrita C, Wallace PK. Evaluation of multiple myeloma measurable residual disease by high sensitivity flow cytometry: An international harmonized approach for data analysis. Cytometry B Clin Cytom. 2022 Mar;102(2):88-106. doi: 10.1002/cyto.b.22053. Epub 2022 Jan 10. PubMed PMID: 35005838.
Soh KT, Tario JD Jr, Hahn TE, Hillengass J, McCarthy PL, Wallace PK. Methodological considerations for the high sensitivity detection of multiple myeloma measurable residual disease. Cytometry B Clin Cytom. 2020 Mar;98(2):161-173. doi: 10.1002/cyto.b.21862. Epub 2019 Dec 23. PubMed PMID: 31868315; PubMed Central PMCID: PMC7741435.
Tario JD Jr, Conway AN, Muirhead KA, Wallace PK. Monitoring Cell Proliferation by Dye Dilution: Considerations for Probe Selection. Methods Mol Biol. 2018;1678:249-299. doi: 10.1007/978-1-4939-7346-0_12. PubMed PMID: 29071683; PubMed Central PMCID: PMC5831513.
Cimato TR, Furlage RL, Conway A, Wallace PK. Simultaneous measurement of human hematopoietic stem and progenitor cells in blood using multicolor flow cytometry. Cytometry B Clin Cytom. 2016 Sep;90(5):415-23. doi: 10.1002/cyto.b.21354. Epub 2016 Feb 17. PubMed PMID: 26663713; PubMed Central PMCID: PMC4967558.
Tario JD Jr, Chen GL, Hahn TE, Pan D, Furlage RL, Zhang Y, Brix L, Halgreen C, Jacobsen K, McCarthy PL, Wallace PK. Dextramer reagents are effective tools for quantifying CMV antigen-specific T cells from peripheral blood samples. Cytometry B Clin Cytom. 2015 Jan;88(1):6-20. doi: 10.1002/cyto.b.21196. Epub 2014 Oct 23. PubMed PMID: 25338522; PubMed Central PMCID: PMC4376327.
Wood BL, Arroz M, Barnett D, DiGiuseppe J, Greig B, Kussick SJ, Oldaker T, Shenkin M, Stone E, Wallace P. 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia. Cytometry B Clin Cytom. 2007;72 Suppl 1:S14-22. doi: 10.1002/cyto.b.20363. PubMed PMID: 17803189.
Wallace PK, Tsang KY, Goldstein J, Correale P, Jarry TM, Schlom J, Guyre PM, Ernstoff MS, Fanger MW. Exogenous antigen targeted to FcgammaRI on myeloid cells is presented in association with MHC class I. J Immunol Methods. 2001 Feb 1;248(1-2):183-94. doi: 10.1016/s0022-1759(00)00351-3. PubMed PMID: 11223078.