Paul Wallace, PhD
Paul Wallace, PhD
Professor of Oncology
Director, Department of Flow & Image Cytometry
Roswell Park Cancer Institute
Associate Professor of Pathology
State University of New York at Buffalo
Areas of Expertise:
Pathology
Flow Cytometry
Special Interests:
Clinical diagnosis and monitoring of leukemia, myelodysplastic syndromes and lymphoma by flow cytometry
Application of flow cytometry to monitoring immune cell function
Immunotherapy of cancer with differentiated myeloid cells
Background
Education and Training:
1989 - 1993, Ph.D., Department of Microbiology & Immunology, Medical College of Pennsylvania, Philadelphia, PA
1976 - 1979, MS, Department of Microbiology and Biochemistry, Idaho State University, Pocatello, ID
Residency:
2003 - present, Adjunct Associate Professor, Norris Cotton Cancer Center, Dept. of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH
1997 - 2003, Research Assistant Professor, Norris Cotton Cancer Center, Dept. of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH
Fellowship:
1994 -1997, Post-Doctoral Fellow, Norris Cotton Cancer Center, Dept. of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH
Professional Memberships:
International Society for Analytical Cytometry
Clinical Cytometry Society
Great Lakes International Imaging and Flow Cytometry Association
- Merzianu M, Wallace PK. Case study interpretation--Portland: Case 4. Acute leukemia of ambiguous lineage, unclassifiable. Cytometry. Part B, Clinical cytometry 2012; 82B3:186-191
- Ahluwalia MS, Wallace PK, Peereboom DM. Flow cytometry as a diagnostic tool in lymphomatous or leukemic meningitis: Ready for prime time?. Cancer 2012; 1187:1747-1753
- Minderman H, Humphrey K, Arcadi JK, Wierzbicki A, Maguire O, Wang ES, Block AW, Sait SN, George TC,Wallace PK. Image cytometry-based detection of aneuploidy by fluorescence in situ hybridization in suspension. Cytometry. Part A 2012; 81A9:776-784
- McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR. Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort. Clinical and experimental allergy 2012; 423:392-404
- Smonskey MT, Block AW, Deeb G, Chanan-Khan AA, Bernstein ZP, Miller KC, Wallace PK, Starostik P.Monoallelic and Biallelic Deletions of 13q14.3 in Chronic Lymphocytic Leukemia: FISH vs miRNA RT-qPCR Detection. American journal of clinical pathology 2012; 1374:641-646
- Hampras SS, Nesline M, Wallace PK, Odunsi K, Furlani N, Davis W, Moysich KB. Predictors of immunosuppressive regulatory T lymphocytes in healthy women. Journal of cancer epidemiology 2012;2012 :191090
- Chanan-Khan AA, Chitta K, Ersing N, Paulus A, Masood A, Sher T, Swaika A, Wallace PK, Mashtare TL Jr, Wilding G, Lee K, Czuczman MS, Borrello I, Bangia N. Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: in vivo evidence of immune activation and antitumour response. British journal of haematology 2011;1554:457-467
- Pankewycz O, Leca N, Kohli R, Wallace PK, Said M, Feng L, Alnimri M, Patel S, Laftavi MR. Low-dose rabbit antithymocyte globulin induction therapy results in prolonged selective lymphocyte depletion irrespective of maintenance immunosuppression. Transplantation proceedings 2011; 432:462-465
- Tario JD Jr , Muirhead KA , Pan D , Munson ME , Wallace PK. Tracking immune cell proliferation and cytotoxic potential using flow cytometry. Methods in molecular biology (Clifton, N.J.) 2011; 699:119-164
- Chanan-Khan A, Zeldis JB, Wallace PK, Czuczman MS, Hernandez-Illatazurri F, Miller A, Padmanabhan S, Lawrence D, Miller KC, Lee K. Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response. Cancer 2011; 11710:2127-2135
- Battiwalla M , Hepgur M , Pan D , McCarthy PL , Ahluwalia MS , Camacho SH , Starostik P , Wallace PK.Multiparameter flow cytometry for the diagnosis and monitoring of small GPI-deficient cellular populations. Cytometry. Part B, Clinical cytometry 2010; 785:348-356
- Segal BH, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Minderman H, Wallace PK, Capitano M, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Blackwell TS. NADPH oxidase limits innate immune responses in the lungs in mice. PloS one 2010; 53:e9631
- Nowak NJ, Wang ES, Wallace PK, Ford L, Liu S, Gaile D, Deeb G, Zeidan A, Sait SNJ, Wetzler M. Recurrent deletion of 9q34 in adult normal karyotype precursor B-cell acute lymphoblastic leukemia. Cancer genetics and cytogenetics 2010; 1991:15-20
- Ly NP, Gold DR, O'Connor GT, Tzianabos AO, Cruikshank WW, Wallace PK, Visness CM, McLoughlin RM, Ruiz-Perez B, Gern JE. Characterization of regulatory T cells in urban newborns. Clinical and molecular allergy : CMA 2009; 7:8
- Qian F, Old LJ, Shrikant P, Lele S, Moysich K, Cheney R, Liao J, Beck A, Frederick PJ, Ayyoub M, Valmori D, Matsuzaki J, Andrews C, Tario Jr JD, Mhawech-Fauceglia P, Wallace PK, Villella J, Odunsi K. Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer. Cancer research 2009;6913:5498-5504
- Akinnusi ME, Paasch LL, Szarpa KR, Wallace PK, El Solh AA. Impact of nasal continuous positive airway pressure therapy on markers of platelet activation in patients with obstructive sleep apnea.Respiration 2009; 771:25-31
- Varadarajan R, Ford L, Sait SNJ, Block AW, Barcos M, Wallace PK, Ramnath N, Wang ES, Wetzler M.Metachronous and synchronous presentation of acute myeloid leukemia and lung cancer. Leukemia research 2009; 339:1208-1211
- Agrawal T, Vats V, Wallace PK, Singh A, Salhan S, Mittal A. Recruitment of myeloid and plasmacytoid dendritic cells in cervical mucosa during Chlamydia trachomatis infection. Clinical microbiology and infection 2009; 151:50-59
- Harb AJ, Wang ES, Wallace PK, Barcos M, Block AW, Sait SNJ, Ford L, Wilding GE, Tan W, Wetzler M.Treating octogenarian and nonagenarian acute myeloid leukemia patients--predictive prognostic models. Cancer 2009; 11511:2472-2481
- Grant J, Bourcier K, Wallace S, Pan D, Conway A, Seyfert-Margolis V, Wallace PK. Validated protocol for FoxP3 reveals increased expression in type 1 diabetes patients. Cytometry. Part B, Clinical cytometry2009; 762:69-78
- Lawrence WG, Varadi G, Entine G, Podniesinski E, Wallace PK. Enhanced red and near infrared detection in flow cytometry using avalanche photodiodes. Cytometry. Part A 2008; 738:767-776
- Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J, Wallace P, Czuczman MS.Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. British journal of haematology 2008; 1401:36-45
- Paszkiewicz GM, Timm EA Jr, Mahoney MC, Wallace PK, Sullivan Nasca MA, Tammela TL, Hutson A, Pauly JL. Increased human buccal cell autofluorescence is a candidate biomarker of tobacco smoking. Cancer epidemiology, biomarkers and prevention 2008; 171:239-244
- Bernstein ZP, Walder H, Adal A, Wallace P, Stewart C, Sumlin A, Kepner J, Mahajan SD, Schwartz SA, Gollnick S, Dougherty T, Poiesz B. Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and light. Current HIV research 2008; 62:152-163
- Agrawal T, Vats V, Wallace PK, Salhan S, Mittal A. Role of cervical dendritic cell subsets, co-stimulatory molecules, cytokine secretion profile and beta-estradiol in development of sequalae to Chlamydia trachomatis infection. Reproductive biology and endocrinology : RB&E 2008; 6:46
- Wallace PK, Tario JD Jr, Fisher JL, Wallace SS, Ernstoff MS, Muirhead KA. Tracking antigen-driven responses by flow cytometry: monitoring proliferation by dye dilution. Cytometry. Part A 2008;7311:1019-1034
- Wood BL, Stone E, Shenkin M, Oldaker T, Kussick SJ, Greig B, DiGiuseppe J, Barnett D, Arroz M, Wallace P. 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia. Cytometry. Part B, Clinical cytometry 2007; 72 Suppl. 1:S14-S22
- Fox CH, Timm EA Jr, Smith SJ, Touyz RM, Bush EG, Wallace PK. A method for measuring intracellular free magnesium concentration in platelets using flow cytometry. Magnesium research 2007; 203:200-207
- Jartti T, Lemanske RF Jr, Gangnon RE, Ruiz-Perez B, Wallace PK, Vrtis RF, Evans MD, Dasilva DF, Salazar LP, Tisler CJ, Jennens-Clough ML, Seroogy CM, Burmeister KA, Gern JE. Association between CD4(+)CD25(high) T cells and atopy in children. Journal of allergy and clinical immunology 2007;1201:177-183
- Cruz RI, Hernandez-Ilizaliturri FJ, Olejniczak S, Deeb G, Knight J, Wallace P, Thurberg BL, Kennedy W, Czuczman MS. CD52 over-expression affects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma. Leukemia and lymphoma 2007; 4812:2424-2436
- Wallace PK, Muirhead KA. Cell tracking 2007: a proliferation of probes and applications. Immunological investigations 2007; 365-6:527-561
- Agrawal T, Vats V, Wallace PK, Salhan S, Mittal A. Cervical cytokine responses in women with primary or recurrent chlamydial infection. Journal of interferon and cytokine research 2007; 273:221-226
- Battiwalla M, Hahn T, Padmanabhan S, Nakamura R, Wallace PK, Segal BH, Almyroudis NG, Radovic M, Bajwa RP, Wu Y, McCarthy PL Jr. Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Biology of blood and marrow transplantation 2007; 137:765-770
- Tario JD Jr, Gray BD, Wallace SS, Muirhead KA, Ohlsson-Wilhelm BM, Wallace PK. Novel lipophilic tracking dyes for monitoring cell proliferation. Immunological investigations 2007; 365-6:861-885
- Fairhurst AM, Wallace PK, Jawad AS, Goulding NJ. Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species. Arthritis research and therapy 2007; 92:R29
- Ramakrishna V, Vasilakos JP, Tario JD Jr, Berger MA, Wallace PK, Keler T. Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells.Journal of translational medicine 2007; 5:5