Partners In Practice Articles
Medical Oncology Update: Advances in Colorectal Cancer Treatment
Arsenal of Surgical Modalities Allows for Tailored Colorectal Cancer Treatment
Our Gastrointestinal Surgery program offers many modalities to provide individualized, tailored treatment for our patients with colorectal cancer.
CLINICAL TRIAL HIGHLIGHT: Regorafenib as maintenance therapy in colorectal cancer patients
by Wen Wee Ma, MBBS
Formerly of Roswell Park
Targeting BRAF Mutation Positive Cancers: Melanoma, Lung and Colorectal
Mitogen-activated protein kinase (MAPK) is a key signaling pathway in a number of cancers.
Roswell Park's Diagnosis and Treatment Approach for Neuroendocrine and Carcinoid Tumors
Neuroendocrine and carcinoid tumors are rare and it takes specialized skills and equipment to diagnose them. Because symptoms may not appear, tumors are often discovered when tests and procedures are performed for other purposes.
BRAF and MEK Inhibitors in Melanoma
High constitutive activity of MAPK pathway has been shown in a majority of melanomas. To date, BRAF and MEK have been shown to be clinically relevant components of this pathway with proven efficacy of agents targeted to BRAF and MEK.
BRAF Inhibitors in Lung Cancer
BRAF mutations have been reported in 3% of non-small cell lung cancers (NSCLC), only in adenocarcinoma sub-type of NSCLC. Although uncommon, BRAF mutations represent a valid potential target as multiple RAF kinase inhibitors are available. BRAF V600E mutation is reported in 2% of NSCLC.
BRAF and MEK Inhibitors in Colorectal Cancer
BRAF mutation has been reported in approximately 10–15% of colorectal cancers. Data also supports presence of BRAF mutations as a poor prognostic factor, as well as a potential biomarker of lack of response to EGFR directed therapy in KRAS wild type colorectal cancer.
Q&A with Dr. Francescutti: Benefits of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Carcinomatosis
Read an interview with Dr. Valerie Francescutti, Surgical Oncologist at Roswell Park, about the benefits of this advanced procedure and her research into why few patients are referred for the possibly life-extending treatment.
Hematopoietic Stem Cell Transplant Program at Roswell Park: Endeavors to Improve Outcomes of Multiple Myeloma
Multiple myeloma is a malignant disorder involving clonal expansion of plasma cells in the bone marrow. It is an incurable hematological malignancy, and therapeutic strategies to achieve long-term control require autologous hematopoietic stem cell transplant.