Sorafenib is the only approved drug for patients with advanced liver cancer. Unfortunately, it is not curative and is also associated with side effects that impact quality of life. At Roswell Park, we are investigating a novel anti-angiogenic agent called tivozanib that is similar to sorafenib but with greater potency and a more favorable toxicity profile.
The two most common malignancies originating within the liver are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). HCCs are one of the most common solid tumors seen worldwide, typically arising in the setting of hepatitis B and C. In the United States, 33,000 new cases of HCC and ICC were estimated for 2014.
Between February 6, 2014 and March 15, 2014 a total of 529 physicians, nurse practitioners, physician assistants, nurses, pharmacists and medical students participated in the online CME activity “Optimizing Dose Intensity for Patients with Metastatic Renal Cell Carcinoma.”
The traditional algorithm of management for metastatic prostate cancer involves androgen deprivation therapy (ADT) as first-line treatment with reservation of chemotherapy for second-line setting after disease progression.
The management of hepatocellular carcinoma (HCC) requires a careful multidisciplinary approach utilizing medical oncologists, surgeons and interventional radiologists. Treatment options require assessment of tumor stage, liver function and performance status.
Patients with localized (stages I and II) pancreatic adenocarcinoma are typically offered surgical removal to give the best chance for long-term survival. Unfortunately, only about 20% of patients fall within these stage categories, and some of these are probably better characterized as "borderline resectable."
Pancreatic resection is associated with significant morbidity. Efforts to reduce hospital stay and speed recovery have resulted in the introduction of minimally invasive surgical techniques. Recently, such approaches for pancreatic resection have been established as feasible and safe.
Pancreatic cancer is a highly desmoplastic disease. Microscopically, the nests of cancer cells are surrounded by thick and abundant stromal tissue that is constituted by collagen, fibroblasts, stellate cells, inflammatory infiltrate and endothelial cells.
Steven Hochwald, MD, FACS, Chief of Gastrointestinal Surgery and Vice Chair of Surgical Oncology, explains how our comprehensive, multidisciplinary team approach to treating colorectal cancer helps preserve quality of life for our surgical patients.