Dr. Higgins joined the Faculty of Roswell Park Comprehensive Cancer Center (Roswell Park) in 2001, and in 2009 was promoted to Associate Professor of Oncology and Associate Member in the Department of Molecular and Cellular Biology. He holds a joint appointment as a Research Associate Professor at the State University of New York at Buffalo.
Before joining the faculty at Roswell Park, Dr. Higgins was a Research Associate in the Department of Human Genetics at Roswell Park where he was involved in the physical mapping of several human genetic diseases including the cancer predisposition condition Beckwith-Wiedemann syndrome (BWS). He was among the first investigators to demonstrate that an alteration in DNA methylation (epimutation) at an imprinting control region could give rise to a human disorder. Dr. Higgins has authors more than 70 peer-reviewed journal articles.