The intrinsic circadian clock regulates a wide variety of processes, including an organism’s response to anticancer genotoxic treatments and immune response. The major goal of my research program is to understand how various stress response pathways cross-talk with the circadian clock and how these pathways can be modulated by the activity of core circadian proteins. For this, we use a variety of cellular and mouse models deficient in various components of the molecular clock. This approach allowed us to identify a previously unknown mechanistic link between the key regulator of immune response NF-kB and core circadian protein CLOCK, which in addition to its bona fide circadian function, directly modulates the activity of p65.
Another research direction of my laboratory is focused on understanding the basic mechanisms of aging, the role of the circadian system in this process and testing potential anti-aging compounds in various models of chronological and premature aging. Overall, our program presents a broad approach to study the role of the circadian system in many biological processes both under normal and stress conditions. It may eventually result in the development of novel therapeutic strategies that will modulate various biological responses through the components of the molecular clock.
Current and former support was provided by National Institute of Health, Alliance Foundation and Everon, Inc.