Dr. Yan is an Assistant Professor of Oncology at Roswell Park Cancer Institute (RPCI). He joined the staff in 2011 after completing his PhD in Physics at the University of Rochester and PhD in Biostatistics at the University at Buffalo. Dr. Yan has more than 12 years of experience in both academic and non-profit research foundation environments, collaborating with clinical and other scientific colleagues on a wide range of activities including study design, analysis plans, project reports, abstracts, manuscripts, and presentations.
He has extensive experience in many programming languages, including R and C++, as well as extensive experience in directing the design and deployment of various high-throughput platforms in cancer-oriented studies. An example of a recently developed tool is OSAT (Yan et al. BMC Genomics. 2012; 13:689. PMC3548766), which is a computational package for sample-to-batch allocations in omics experiments in order to minimize the impact of batch effects.
Sucheston-Campbell L, Preus L, Spellman S, Pasquini MC, McCarthy PL, Onel K, Zhu X, Haiman C, Stram D, Pooler L, Shen X, Zhu Q, Yan L, Liu Q, Hu Q, Liu S, Clay A, Battaglia S, Hahn T, Functional Single Nucleotide Polymorphisms (SNPs) in the Major Histocompatibility Complex (MHC) Class II Region Are Associated with Overall Survival (OS) after HLA Matched Unrelated Donor BMT: Results from the Discovery-BMT Study. Biology of Blood and Marrow Transplant. 2016 Mar 1;22(3):S72–3.
Hahn TE, Preus L, McCarthy PL, Pasquini MC, Onel K, Zhu X, Spellman S, Haiman C, Stram DO, Pooler L, Sheng X, Zhu Q, Yan L, Liu Q, Hu Q, Liu S, Clay A, Battaglia S, Tritchler D, Sucheston-Campbell L, Genome-Wide Association Study of Cause-Specific Transplant-Related Mortality (TRM) after HLA-Matched Unrelated Donor Allogeneic BMT for Acute Leukemia or Myelodysplastic Syndrome Demonstrates Unique, Non-Overlapping Genetic Associations (Discovery-BMT). Biology of Blood and Marrow Transplant. 2016 Mar 1;22(3):S74–5.
Yan L, Tian L, Liu S, Combining large number of weak biomarkers based on AUC. Stat Med. 2015 Dec 20;34(29):3811–30.
Hahn T, Sucheston-Campbell LE, Preus L, Zhu X, Hansen JA, Martin PJ, Yan L, Song Liu S, Spellman S, Tritchler D, Clay A, Onel K, Pasquini M, McCarthy PL, Establishment of Definitions and Review Process for Consistent Adjudication of Cause-specific Mortality after Allogeneic Unrelated-donor Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2015 Sep;21(9):1679–86.
Mhawech-Fauceglia P, Yan L, Sharifian M, Ren X, Liu S, Kim G, et al., Stromal Expression of Fibroblast Activation Protein Alpha (FAP) Predicts Platinum Resistance and Shorter Recurrence in patients with Epithelial Ovarian Cancer. Cancer Microenviron. 2014 Oct 21.
Khoury T, Yan L, Liu S, Bshara W, Oncotype DX RT-qPCR Assay for ER and PR Correlation With IHC: A Study of 3 Different Clones. Appl Immunohistochem Mol Morphol. 2014 Jul 2;
Zhao H, Shen J, Hu Q, Davis W, Medico L, Wang D, Yan L, Guo Y, Liu B, Qin M, Nesline M, Zhu Q, Yao S, Ambrosone C, Liu S, Effects of preanalytic variables on circulating microRNAs in whole blood. Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2643–8.
Shen J, Hu Q, Schrauder M, Yan L, Wang D, Medico L, et al., Circulating miR-148b and miR-133a as biomarkers for breast cancer detection. Oncotarget. 2014 Jul 30;5(14):5284–94.
Hahn T, Sucheston-Campbell L, Preus L, Onel K, Zhu X, Liu S, Yan L, Tritchler D, Pasquini MC, McCarthy PL, Value of a Consensus Panel to Adjudicate Cause-Specific Mortality after Unrelated Donor Allogeneic Hematopoietic Cell Transplantation (URD-HCT) for Use As the Primary Endpoint in a Genome-Wide Association Study (GWAS). Biology of Blood and Marrow Transplant. 2014 Feb 1;20(2):S35–6.
Singh PK, Preus L, Hu Q, Yan L, Long MD, Morrison CD, et al., Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients. Oncotarget. 2014 Feb 15;5(3):824–40.
Ambrosone CB, Young AC, Sucheston LE, Wang D, Yan L, Liu S, et al., Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry. Oncotarget. 2014 Jan 15;5(1):237–48.
Szigeti K, Kellermayer B, Lentini JM, Trummer B, Lal D, Doody RS, Yan L, Liu S, Ma C, Ordered subset analysis of copy number variation association with age at onset of Alzheimer’s disease. J Alzheimers Dis. 2014;41(4):1063–71.
Shen J, Yan L, Liu S, Ambrosone CB, Zhao H, Plasma Metabolomic Profiles in Breast Cancer Patients and Healthy Controls: By Race and Tumor Receptor Subtypes. Transl Oncol. 2013 Dec 1;6(6):757–65.
Shen H, Morrison CD, Zhang J, Underwood III W, Yang N, Frangou C, Eng K, Head K, Bollag RJ, Kavuri SK, Rojiani AM, Li Y, Yan L, Hill A, Woloszynska-Read A, Wang J, Liu S, Trump DL, and Candace JS, 6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer. Oncotarget [Internet]. 2013 Oct 30 [cited 2013 Nov 13];4(9).
Szigeti K, Trummer B, Lal D, Doody RS, Yan L, Liu S, et al. Genome-Wide Scan for Copy Number Variation Association with Biomarker Quantitative Trait Loci in Aging. European Journal of Inflammation. 2014 May 1;12(2):267–76.
Garcia H, Miecznikowski JC, Safina A, Commane M, Ruusulehto A, Kilpinen S, Leach RW, Attwood K, Yan L, Degan S, Omilian AR, Guryanova O, Papantonopoulou O, Wang J, Buck M, Liu S, Morrison C, and Gurova KV, Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers. Cell Reports. 2013 Jul 11;4(1):159–73.
Mhawech-Fauceglia P, Yan L, Liu S, Pejovic T, ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium: a study of 401 cases. Histopathology. 2013 Jun;62(7):976–85.
Szigeti K, Lal D, Li Y, Doody RS, Wilhelmsen K, Yan L, et al., Genome-wide scan for copy number variation association with age at onset of Alzheimer’s disease. J Alzheimers Dis. 2013;33(2):517–23.
Shionome Y, Yan L, Liu S, Saeki T, Ouchi T, Integrity of p53 Associated Pathways Determines Induction of Apoptosis of Tumor Cells Resistant to Aurora-A Kinase Inhibitors. PLoS ONE. 2013;8(1):e55457.
Khoury T, Karabakhtsian RG, Mattson D, Yan L, Syriac S, Habib F, et al., Pleomorphic lobular carcinoma in situ of the breast: clinicopathologic review of 47 cases. Histopathology. 2014 Jun;64(7):981-93
Yan L, Ma C, Wang D, Hu Q, Qin M, Conroy J , Sucheston L, et al., “OSAT: a Tool for Sample-to-batch Allocations in Genomics Experiments.” BMC Genomics 13, no. 1 (December 10, 2012): 689.
Jalal K, Carter R, Yan L, Barczykowski A, Duffner PK, “Does galactocerebrosidase activity predict krabbe phenotype?” Pediatr Neurol. Vol. 47(5), 324(2012).
Zhao H, Shen J, Wang D, Gregory S, Medico L, Hu Q, Yan L, Odunsi K, Lele S, Liu S, “Associations between Gene Expression Variations and Ovarian Cancer Risk Alleles Identified from Genome Wide Association Studies.” PLoS One. Vol. 7(11), e47962(2012).
Barczykowski AL, Foss AH, Duffner PK, Yan L, Carter RL, “Death rates in the U.S. due to Krabbe disease and related leukodystrophy and lysosomal storage diseases.” Am J Med Genet A. Vol 158A(11), 2835(2012)
Tian, L., Li, X., Yan, L, “Testing equality of generalized treatment effects.” J Biopharm Stat Vol.22, 582 (2012).
Duffner PK, Barczykowski A, Kay DM, Jalal K, Yan L, Abdelhalim A, Gill S, Gill AL, Carter R, “Later onset phenotypes of Krabbe disease: results of the world-wide registry”. Pediatr Neurol. Vol. 46(5), 298(2012).
Wang D, Yan L, Hu Q, Sucheston L, Higgins M, Ambrosone C, Johnson C, Smiraglia, D, Liu S, “IMA: An R package for high-throughput analysis of Illumina’s 450K Infinium methylation data.” Bioinformatics Vol. 28, 729(2012).
Hu Q, Wang D, Yan L, Zhao H and Liu S, “VPA: an R package for analyzing sequencing variants with user-specified frequency pattern.” BMC Research Notes Vol. 5, 31(2012).
Shen J, Wang D,Gregory S, Medico L, Hu Q, Yan L, Odunsi K, Lele S B, Ambrosone C, Liu S, Zhao H, “Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer Carcinogenesis.” Vol. 33, 604(2012).
Duffner P, Barczykowski A, Jalal K, Yan L, Kay D, and Carter R, “Early infantile Krabbe disease: results of the World-Wide Krabbe Registry.” Pediatr Neurol. Vol.45(3), 141(2011)
Tian, L.,Vexler, A., Yan, L. and Schisterman, E, “Confidence Interval Estimation of the Difference Between Paired AUCs Based on Combined Biomarkers” JSPI, Vol.139, 3725(2009).