Research Interests:
- Statistical Biomarker Discovery and Validation Methods
- Translational Bioinformatics
- Pharmacogenomics
- Survival Analysis and Competing Risk Analysis
- Precision Medicine
- Computational methods for genomic and other big data
Biography
Li Yan, PhD, is Associate Professor of Oncology in the Department of Biostatistics and Bioinformatics of Roswell Park Comprehensive Cancer Center. His key research interests and expertise include statistical methods and software for omics data, biomarker discovery and statistical methods for combination of biomarkers, survival analysis in translational and clinical research, parallel and distributed computing methods for genomic cancer research and other big data, and experimental design for omics studies. His collaboration works cover wide range of subject areas including breast, prostate, pancreas and other cancers, blood and marrow transplant, Alzheimer's disease and other diseases. He has authored or co-authored over 130 peer-reviewed methodological and collaborative publications.
Positions
Roswell Park Comprehensive Cancer Center
- Associate Professor of Oncology
- Department of Biostatistics and Bioinformatics
State University of New York at Buffalo
- Research Assistant Professor
Background
Education and Training
- 2013 - PhD - Biostatistics, SUNY at Buffalo, NY
- 2002 - PhD - Physics, University of Rochester, NY
- 1988 - BS - Physics, Shandong University, China
Professional Memberships
- American Statistical Association
Honors & Awards
- 1998-2002 - Kodak Fellowship
Publications
Yao S, Cheng TYD, Elkhanany A, Yan L, Omilian A, Abrams SI, Evans S, Hong CC, Qi Q, Davis W, Liu S, Bandera EV, Odunsi K, Takabe K, Khoury T, Ambrosone CB. Breast Tumor Microenvironment in Black Women: A Distinct Signature of CD8+ T-Cell Exhaustion. JNCI: Journal of the National Cancer Institute. 2021 Aug 1;113(8):1036–1043.
Oshi M, Asaoka M, Tokumaru Y, Yan L†, Matsuyama R, Ishikawa T, Endo I, Takabe K. CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer. Int J Mol Sci. 2020 Sep 22;21(18). PMCID: PMC7555570
Buas MF, Drescher CW, Urban N, Li CI, Bettcher L, Hait NC, Moysich KB, Odunsi K, Raftery D, Yan L. Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass. Sci Rep. 2021 Sep 13;11(1):18156. PMCID: PMC8438087
Chen J, Ali MW, Yan L, Dighe SG, Dai JY, Vaughan TL, Casey G, Buas MF. Prioritization and functional analysis of GWAS risk loci for Barrett’s esophagus and esophageal adenocarcinoma. Hum Mol Genet. 2021 Sep 9;31(3):410–422. PMCID: PMC8825357
Yan L. Confidence interval estimation of the common mean of several gamma populations. PLOS ONE. Public Library of Science; 2022 Jun 17;17(6):e0269971.
Yan, L., Tian, L. & Liu S. (2015). Combining large number of weak biomarkers based on AUC. Stat Med, 34(29), 3811–3830. PMID: 26227901