Jason Muhitch, PhD

Assistant Professor of Oncology
Departments of Urology and Immunology
Roswell Park Comprehensive Cancer Center
Areas of Expertise: 
Radiation-induced anti-tumor immunity
Tumor-conditioned monocyte/macrophage plasticity
Renal cell carcinoma
Molecular determinants of intratumoral T cell infiltration
Special Interests: 
Dynamic imaging of T cell function
Combinatorial approaches to improve immunotherapy

Biography

The goal of my laboratory is to elucidate the molecular mechanisms that limit renal cell carcinoma patient responses to immunotherapy. The laboratory’s translational studies are concentrated on enhancing anti-tumor immunity through improved myeloid cell function and cytolytic T cell activity within renal cell carcinoma. Our laboratory’s findings from a pilot trial in metastatic renal cell carcinoma combining high-dose radiation of kidney tumors with surgical resection, provide a glimpse into the immune activating effects of radiation in human cancer. The laboratory’s most recent studies performed in collaboration with Dr. Scott Abrams shed light on the role key transcription factors at play in macrophage behavior and patient outcome.

Background

Education and Training: 
PhD, State University of New York at Buffalo, Biological Sciences, 2013
Professional Memberships: 
The American Association of Immunologists
Radiation Research Society
American Urological Association
Society for Basic Urologic Research