Predisposition to cancer and cancer progression can result from gene mutations that cause elevated rates of genetic damage. Similarly, carcinogens, including some that are used in chemotherapy during cancer treatment, act by damaging the DNA. A new study from Roswell Park Cancer Institute offers insights into the mechanisms that can lead to genetic mutations and proposes opportunities for developing prognostic tests for specific blood disorders and blood cancers based on these striking findings.

Metastatic prostate cancer, or prostate cancer that has spread to other organs, is incurable. In new research published in the journal Science, Roswell Park Cancer Institute scientists have identified two gatekeeper genes that allow prostate cancer to progress and resist treatment. Their work illuminates the mechanisms behind lineage plasticity, the ability of prostate cancer to adapt to therapy, and highlights opportunities to disrupt and even reverse this deadly process.

Forty-one physicians from Roswell Park Cancer Institute are included in the Castle Connolly Medical, Ltd. prestigious America’s Top Doctors® list in 2017. The annual directory offered by the healthcare research and information company is designed to help guide consumers to America’s top doctors.

One of the main reasons cancer remains difficult to treat is that cancer cells have developed a multitude of mechanisms that allow them to evade destruction by the immune system. One of these escape mechanisms involves a type of immune cell called myeloid-derived suppressor cells (MDSCs). A recent study led by Sharon Evans, PhD, Professor of Oncology and Immunology at Roswell Park Cancer Institute, provides new insight into how MDSCs circumvent immune attack and offer the potential for improving cancer immunotherapy. The research has been published today in the journal eLife.

The Erie County Sheriff’s Office and Buffalo Police Department (BPD) snipped, clipped and shaved their way to cancer cures today, raising a collective $39,400 to support cancer research and patient-care programs at Roswell Park Cancer Institute through the Goin’ Bald for Bucks program.

Hookah tobacco labeling is misleading for consumers, according to new research that analyzed nicotine and pH levels of the tobacco. The study, led by Roswell Park Cancer Institute scientists, is published online ahead of print by the journal Tobacco Regulatory Science.