Anna Bianchi-Smiraglia, PhD

Assistant Professor of Oncology
Cell Stress Biology
Roswell Park Comprehensive Cancer Center
Areas of Expertise: 
Breast cancer
Melanoma
GTP metabolism
Tumor-microenvironment interactions
Special Interests: 
Breast cancer
Metabolism
Metastasis
Tumor-microenvironment interactions

Biography

Dr. Anna Bianchi-Smiraglia joined the faculty of the Cell Stress Biology Department at Roswell Park Comprehensive Cancer Center in October 2018 as an Assistant Member and Assistant Professor of Oncology. Anna earned her MS in Industrial Biotechnology from the University of Milan, Italy and her PhD in Cellular and Molecular Biology from The State University of New York at Buffalo, within the Roswell Park division. As a graduate student, she characterized the role of integrin beta5 in the TGF-beta induced EMT in mammary epithelial cells and its role in driving the aggressive phenotype of breast carcinoma cells (Cell Cycle, 2010; Oncogene, 2013; Cell Cycle, 2013).

Dr. Bianchi-Smiraglia performed her post-doctoral training in the laboratory of Dr. Mikhail Nikiforov and was awarded an NIH F32 Fellowship to study the role of GTP metabolism in melanoma invasion and progression. Her work contributed to seminal papers in the field of GTP and invasion as well as resulted in the generation and characterization of the first genetically engineered fluorescent GTP reporters for detection of intracellular GTP levels in live cells (Cell Reports, 2013; Cell Death and Differentiation, 2015; Oncogene, 2017; Nature Methods, 2017). Additionally, Anna identified a novel transcriptional regulator of polyamine metabolism and a drug to suppress this pathway in multiple myeloma (Journal of Clinical Investigation, 2018).

Her laboratory is currently interested in understanding the metabolic pathways and signaling events that contribute to breast cancer and neuroblastoma progression, as well as identifying novel therapeutic options for these cancers.

Background

Education and Training: 
2012 - PhD - State University of New York at Buffalo, Roswell Park Division, Buffalo, NY
1997-2002 - MS - Industrial Biotechnologies, University of Milan, Milan, Italy
Fellowship: 
2015-2018 - Ruth L. Kirschstein National Research Service Award (NIH-F32), GTP metabolism, Roswell Park Comprehensive Cancer Center
Professional Memberships: 
American Association of Cancer Research (AACR)
Honors and Awards: 
2015 - Ruth L. Kirschstein National Research Service Award (NIH-F32)
2011 - Susan G. Komen for the Cure, Scholar-in-Training Award
Professional Experience: 
2012-2018 - Post-Doctoral Fellow - Roswell Park Cancer Institute, Department of Cell Stress Biology, Buffalo, NY
2007-2012 - Graduate Student - Roswell Park Cancer Institute, Department of Cancer Genetics, Buffalo, NY
2006-2007 - Research Affiliate - Roswell Park Cancer Institute, Department of Immunology, Buffalo, NY
2002-2006 - Research Affiliate - University of Milan, Department of Medical Chemistry, Biochemistry and Biotechnology