Specializing In:
- Human genetics
- Cancer genomics
- Computational biology
Research Interests:
- DNA replication
- Genome stability
- Mutations
- Genetic variation
- Quantitative trait loci
Biography
Amnon Koren obtained his PhD from the Weizmann Institute of Science in Israel under the mentorship of Naama Barkai, working on genomic approaches for measuring DNA replication timing. He was then a postdoctoral fellow at Harvard Medical School and the Broad Institute of Harvard and MIT, where he worked with Steven McCarroll on human genetics approaches for studying inter-individual variation in DNA replication timing.
He was an Assistant Professor at Cornell University before joining the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center as an Associate Professor in 2024.
His lab focuses on genomic and computational approaches for studying DNA replication dynamics and mutation patterns in human cells and in cancer.
Positions
Roswell Park Comprehensive Cancer Center
- Associate Professor of Oncology
- Department of Molecular and Cellular Biology
Background
Education and Training
- 2008 - PhD - Genetics, The Weizmann Institute of Science, Rehovot, Israel
Fellowship
- 2010-2015 - Postdoctoral Fellow, Genetics, Harvard Medical School and the Broad Institute of Harvard and MIT, Cambridge, MA
Professional Memberships
- The American Society of Human Genetics
Honors & Awards
- 2016 - NIH Director's New Innovator Award
Research Overview
DNA replication is the fundamental mechanism of genetic inheritance, but also a major opportunity for the introduction of mutations. DNA is replicated in a highly organized manner, with different regions of the genome replicating at different times. The Koren lab studies the causes and consequences of these DNA replication timing programs. We apply genomic approaches, integrating experimental and computational biology, to profile replication timing in different people and in different cells.
Publications
- Edwards MM, Wang N, Massey DJ, Bhatele S, Egli D, Koren A. Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells. Cell Rep. 2024;43(1):113664. Epub 20240108. doi: 10.1016/j.celrep.2023.113664. PubMed PMID: 38194345; PMCID: PMC11231959.
- Caballero M, Koren A. The landscape of somatic mutations in lymphoblastoid cell lines. Cell Genom. 2023 May 2;3(6):100305. doi: 10.1016/j.xgen.2023.100305. Erratum in: Cell Genom. 2023 Sep 13;3(9):100407. doi: 10.1016/j.xgen.2023.100407. PMID: 37388907; PMCID: PMC10300552.
- Bracci AN, Dallmann A, Ding Q, Hubisz MJ, Caballero M, Koren A. The evolution of the human DNA replication timing program. Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2213896120. doi: 10.1073/pnas.2213896120. Epub 2023 Feb 27. PMID: 36848554; PMCID: PMC10013799.
- Massey DJ, Koren A. High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control. Nat Commun. 2022 May 3;13(1):2402. doi: 10.1038/s41467-022-30212-y. PMID: 35504890; PMCID: PMC9065153.
- Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clark AG, Koren A. The genetic architecture of DNA replication timing in human pluripotent stem cells. Nat Commun. 2021 Nov 19;12(1):6746. doi: 10.1038/s41467-021-27115-9. PMID: 34799581; PMCID: PMC8604924.
- Koren A, Handsaker RE, Kamitaki N, Karlić R, Ghosh S, Polak P, Eggan K, McCarroll SA. Genetic variation in human DNA replication timing. Cell. 2014 Nov 20;159(5):1015-1026. doi: 10.1016/j.cell.2014.10.025. Epub 2014 Nov 13. PMID: 25416942; PMCID: PMC4359889.