Specializing In:
Human genetics Cancer genomics Computational biologyResearch Interests:
DNA replication Genome stability Mutations Genetic variation Quantitative trait lociAbout Amnon Koren
Biography:
Amnon Koren obtained his PhD from the Weizmann Institute of Science in Israel under the mentorship of Naama Barkai, working on genomic approaches for measuring DNA replication timing. He was then a postdoctoral fellow at Harvard Medical School and the Broad Institute of Harvard and MIT, where he worked with Steven McCarroll on human genetics approaches for studying inter-individual variation in DNA replication timing.
He was an Assistant Professor at Cornell University before joining the Department of Molecular and Cellular Biology at Roswell Park Comprehensive Cancer Center as an Associate Professor in 2024.
His lab focuses on genomic and computational approaches for studying DNA replication dynamics and mutation patterns in human cells and in cancer.
Positions
- Associate Professor of Oncology
- Department of Molecular and Cellular Biology
Background
Education and Training:
- 2008 - PhD - Genetics, The Weizmann Institute of Science, Rehovot, Israel
Fellowship:
- 2010-2015 - Postdoctoral Fellow, Genetics, Harvard Medical School and the Broad Institute of Harvard and MIT, Cambridge, MA
Professional Memberships:
- The American Society of Human Genetics
Honors & Awards:
- 2016 - NIH Director's New Innovator Award
Research
Research Overview:
DNA replication is the fundamental mechanism of genetic inheritance, but also a major opportunity for the introduction of mutations. DNA is replicated in a highly organized manner, with different regions of the genome replicating at different times. The Koren lab studies the causes and consequences of these DNA replication timing programs. We apply genomic approaches, integrating experimental and computational biology, to profile replication timing in different people and in different cells.
Publications
The landscape of somatic mutations in lymphoblastoid cell lines
Caballero M, Koren A
Cell Genomics 3(6):100305 (2023)
The evolution of the human DNA replication timing program
Bracci AN, Dallmann A, Ding Q, Hubisz MJ, Caballero M, Koren A
PNAS 120(10):e2213896120 (2023)
High-throughput analysis of DNA replication in single human cells reveals the complex nature of replication timing control
Massey DJ, Koren A
Nature Communications 13(1):2402 (2022)
The genetic architecture of DNA replication timing in human pluripotent stem cells
Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clark AG, Koren A
Nature Communications 12:6746 (2021)
Genetic variation in human DNA replication timing
Koren A, Handsaker R, Kamitaki N, Karlic R, Ghosh S, Polak P, Eggan K, McCarroll SA
Cell 159(5):1015-1026 (2014)