Alan Hutson

Alan Hutson

PhD, MA

Special Interests:

Clinical trial design, computational methods and order statistics

About Me

Biography:

Dr. Hutson is Chair of Biostatistics and Bioinformatics at Roswell Park and Associate Director of the Biostatistics Shared Resource. He received his B.A. (1988) and M.A. (1990) in Statistics from the State University of New York (SUNY) at Buffalo. He then worked for Otsuka America Pharmaceuticals for two years as a biostatistician. Dr. Hutson then received his M.A. (1993) and Ph.D. (1996) in Statistics from the University of Rochester. His Ph.D. advisor was Professor Govind Mudholkar, a world-renown researcher in Statistics and Biostatistics. Dr. Hutson was hired as a biostatistician at the University of Florida in 1996 as a Research Assistant Professor and worked his way to a tenured Associate Professor. He had several roles at the University of Florida including Interim Director of the Division of Biostatistics and Director of the General Clinical Research Informatics Core. Dr. Hutson moved to the University at Buffalo in 2002 as an Associate Professor and Chief of the Division of Biostatistics. He was the founding chair of the new Department of Biostatistics in 2003 and became a full professor in 2007. Dr. Hutson’s accomplishments as Chair included the implementation of several new undergraduate and graduate degree programs and a substantial growth in the size and quality of the department faculty and students. In 2005 Dr. Hutson also became Chair of Biostatistics (now Biostatistics and Bioinformatics) at Roswell Park Comprehensive Cancer Center (Roswell Park), was appointed to Professor of Oncology and was the Director of the Core Cancer Center Biostatistics Core. Dr. Hutson helped implement the new Bioinformatics Core at Roswell Park. Dr. Hutson is Fellow of the American Statistical Association. He is Associate Editor of Communications in Statistics, Associate Editor of the Sri Lankan Journal of Applied Statistics and is a New York State NYSTAR Distinguished Professor. Dr. Hutson’s has membership on several data safety and monitoring boards and has served on several high level scientific review panels. He has over 200 peer reviewed publications. In 2013 Dr. Hutson was inducted into the Delta Omega Public Health Honor Society, Gamma Lambda Chapter. Dr. Hutson’s methodological work focuses on nonparametric methods for biostatistical applications as it pertains to statistical functionals. He has several years of experience in the design and analysis of clinical trials.


Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Chair and Professor of Oncology
  • Department of Biostatistics and Bioinformatics

Background

Education and Training:

  • 1996 - PhD - Statistics - University of Rochester
  • 1993 - MA - Statistics - University of Rochester
  • 1993 - MA - Statistics - State University of New York at Buffalo
  • 1988 - BA - Statistics - State University of New York at Buffalo

Professional Memberships:

  • Member American Statistical Association
  • Institute for Mathematical Statistics
  • American Public Health Association
  • Society for Controlled Clinical Trials

Publications

Hutson AD. A multi-rater nonparametric test of agreement and corresponding agreement plot. Computational Statistics and Data Analysis 2010; 54(1):109-119

McCormack RF, Hutson A. Can computed tomography angiography of the brain replace lumbar puncture in the evaluation of acute-onset headache after a negative noncontrast cranial computed tomography scan?. Academic Emergency Medicine 2010; 17(4):444-451

Pauly JL, Smith LA, Rickert MH, Hutson A, Paszkiewicz GM. Review: Is lung inflammation associated with microbes and microbial toxins in cigarette tobacco smoke?. Immunologic Research 2010; 46(1-3):127-136

Quan L, Hutson A, Demant P. A locus on chromosome 8 controlling tumor regionality-a new type of tumor diversity in the mouse lung. International Journal of Cancer 2010; 126(11):2603-2613

Smith LA, Paszkiewicz GM, Hutson AD, Pauly JL. Inflammatory response of lung macrophages and epithelial cells to tobacco smoke: a literature review of ex vivo investigations. Immunologic Research 2010; 46(1-3):94-126

Kariapper M, Balogh Lajos, Hutson A, Slocum HK, Baumann H, Lesniak W, Kariapper IA, Tan W, Tracy E, Kasturirangan V, Khan MK. Dendrimer nanoparticle effects on the microenvironment: Examination of cellular motility, mitosis and inflammation. Proceedings of the American Association for Cancer Research Annual Meeting 2010; 51:549

Michalek AM, Hutson AD, Wicher CP, Trump DL. The costs and underappreciated consequences of research misconduct: a case study. PLoS Medicine 2010; 7(8):e1000318

Wang D, Hutson AD, Miecznikowski JC. L-moment estimation for parametric survival models given censored data. Statistical Methodology 2010; 7(6):655-667

Patel AV, Khorana AA, Bharthuar A, Kuvshinoff BW, Mackman N, Hutson A, Iyer RV. Tissue factor is associated with a prothrombotic state in pancreaticobiliary cancer (PBC). Annals of Surgical Oncology 2010; 17(Suppl. 1):S96

Mashtare Jr TL , Hutson AD. Utilizing the flexibility of the epsilon-skew-normal distribution for tobit regression problems. Communications in Statistics: theory and methods 2011; 40(3):408-423

Mashtare Jr TL , Hutson AD. An exact bootstrap approach towards modification of the Harrell-Davis quantile function estimator for censored data. Journal of Nonparametric Statistics 2010; 22(8):1039-1051

Bharthuar A, Khorana AA, Mackman N, Hutson A, Patel A, Iyer RV. Association of tissue factor with prothrombotic state in pancreaticobiliary cancer (PBC): 2010 Gastrointestinal Cancers Symposium. Journal of Clinical Oncology 2010; 28(15 Suppl.): Abstract #158

Jayaprakash V, Bogaards A, Frustino J, Gill SR, Wilson BC, Mang TS, Hutson AD, Marshall JR, Johnson T, Ramananda S, Moysich KB, Popat SR, Loree TR, Rigual NR, Merzianu M, Sullivan M, Reid ME. Autofluorescence-guided surveillance for oral cancer. Cancer Prevention Research (Philadelphia, Pa.)2009; 2(11):966-974

Jewell EL, Darcy KM, Hutson A, Lee PS, Havrilesky LJ, Grace LA, Berchuck A, Secord AA. Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study. Gynecologic Oncology2009; 115(3):424-429

Kurey I, Demant P, Hutson A, Stassen AP, Svobodova M, Grekov I, Trtkova K, Quan L, Slapnickova M, Havelkova H, Kobets T, Lipoldova M. Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics 2009; 61(9):619-633

Markman M, Brady M, Hutson A, Berek JS. Survival after second-line intraperitoneal therapy for the treatment of epithelial ovarian cancer: the Gynecologic Oncology Group experience. International Journal of Gynecological Cancer 2009; 19(2):223-229

Nair BM, Kariapper MST, Lesniak WG, Tan W, Hutson A, Khan MK, Balogh LP.Toxicity evaluation of gold-dendrimer composite nanodevices in vitro - Difference found between tumour and proliferating endothelial cells. Nanotoxicology 2009; 3(2):139-151

Rubatt JM, Darcy KM, Hutson A, Bean SM, Havrilesky LJ, Grace LA, Berchuck A, Secord AA. Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. Gynecologic Oncology 2009; 112(3):469-474

Quan L, Stassen APM, Ruivenkamp CAL, van Wezel T, Fijneman RJA, Hutson A, Kakarlapudi N, Hart AAM, Demant P. Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats. PloS One 2011; 6(2):e14727

Vexler A, Shan G, Kim S, Tsai W-M, Tian L, Hutson AD. An empirical likelihood ratio based goodness-of-fit test for Inverse Gaussian distributions. Journal of statistical planning and inference 2011; 141(6):2128-2140

Vexler A, Yu J, Hutson AD. Likelihood testing populations modeled by autoregressive process subject to the limit of detection in applications to longitudinal biomedical data. Journal of Applied Statistics 2011; 38(7):1333-1346

Wang D , hutson, A. A fractional order statistic towards defining a smooth quantile function for discrete data. Journal of Statistical Planning and Inference 2011; 141(9):3142-3150

Bharali DJ, Pradhan V, Elkin G, Qi W, Hutson A, Mousa SA, Thanavala Y.Novel nanoparticles for the delivery of recombinant hepatitis B vaccine. Nanomedicine : Nanotechnology, Biology, and Medicine 2008; 4(4):311-317

Balogh L, Minc L, Hutson A, Tan W, Mamou F, Bolton B, Llanes M, El-Jawahri A, Kariapper MS, Sung LY, Zhang C, Lesniak W, Nair BM, Nigavekar SS, Khan MK. Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models. Nanomedicine : Nanotechnology, Biology, and Medicine 2007; 3(4):281-296

Fakih MG, French R, Hutson A, Brattain MG, Schwartz J, Creaven PJ, Bernardi RJ, Black JD, Muindi JR, Trump DL, Johnson CS. A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors. Clinical Cancer Research 2007;13(4):1216-1223

Gaile DP, Hutson A, Java J, Conroy JM, McQuaid D, Rossi M, J Nowak N.Errors in centering of array data can induce biases in correlation estimates.Journal of Statistical Planning and Inference 2007; 137(11):3446-3461

Guru KA, Seereiter PJ, Sfakianos JP, Hutson AD, Mohler JL. Is a cystogram necessary after robot-assisted radical prostatectomy?. Urologic Oncology 2007; 25(6):465-467

Lesniak WG, Kariapper MS, Nair BM, Tan W, Hutson A, Balogh LP, Khan MK.Synthesis and characterization of PAMAM dendrimer-based multifunctional nanodevices for targeting alphavbeta3 integrins. Bioconjugate Chemistry 2007; 18(4):1148-1154

Secord AA, Darcy KM, Hutson A, Lee PS, Havrilesky LJ, Grace LA, Berchuck A, Gynecologic Oncology Group study. Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. Gynecologic Oncology 2007; 106(1):221-232

Segal BH, Davidson BA, Hutson AD, Russo TA, Holm BA, Mullan B, Habitzruther M, Holland SM, Knight PR 3rd. Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.American journal of physiology. Lung Cellular and Molecular Physiology 2007; 292(3):L760-L768

Wei LH, Baumann H, Tracy E, Wang Y, Hutson A, Rose-John S, Henderson BW. Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling. British Journal of Cancer 2007; 97(11):1513-1522

Paszkiewicz GM, Timm EA Jr, Mahoney MC, Wallace PK, Sullivan Nasca MA, Tammela TL, Hutson A, Pauly JL. Increased human buccal cell autofluorescence is a candidate biomarker of tobacco smoking. Cancer Epidemiology, Biomarkers and Prevention 2008; 17(1):239-244

Quick SK, Muti P, Marian C, Edge SB, Seddon M, Lehman TA, Modali R, Vito D, Trevisan M, Hutson AD, McCann SE, Platek ME, Nie J, Shields PG, Freudenheim JL. Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk. Cancer Epidemiology, Biomarkers and Prevention 2008; 17(5):1082-1087

Weiss JR, Baer MR, Ambrosone CB, Blanco JG, Hutson A, Ford LA, Moysich KB. Concordance of pharmacogenetic polymorphisms in tumor and germ line DNA in adult patients with acute myeloid leukemia. Cancer Epidemiology, Biomarkers and Prevention 2007; 16(5):1038-1041

Miecznikowski JC, Wang D, Hutson A. Bootstrap MISE estimators to obtain bandwidth for kernel density estimation. Communications in Statistics: Simulation and Computation 2010; 39(7):1455-1469

Fora A, Fakih M, Scheib S, Hanna T, Raczyk C, Hutson A, Gottlieb R. New CT treatment response score for predicting survival in patients with metastatic colorectal carcinoma: A pilot study. Journal of Clinical Oncology 2009; 27(15 Suppl.): Abstract #e15026

Iyer R, Khushalani N, Tan W, Litwin A, LeVea C, Hutson A, Tucker C, Ma W, Fakih M, Adjei A. A phase II study of erlotinib in patients (pts) with advanced pancreatic cancer (APC) who are refractory to gemcitabine (G). European Journal of Cancer (Oxford, England : 1990) 2009; 7(2):391

Khan MK, Kariapper MST, Kasturirangan V, Tracy E, Lesniak W, Hutson A, Baumann H, Balogh LP. In vivo inflammation study of PAMAM dendrimer nanoparticles in mice. Proceedings of the American Association for Cancer Research Annual Meeting 2009; 50:373

Meguerditchian A, Huang H, Pak Y, Sossey-Alaoui K, Watroba N, Hutson A, Kulkarni S, Edge SB, Geradts J, Coignet LJ. CD24/FLJ 13639 expression ratio predicts worse outcome in invasive breast cancer. Annals of Surgical Oncology 2007; 14(2 Suppl.):35

Rubatt JM, Darcy KM, Hutson A, Bean SM, Havrilesky LJ, Lee PS, Grace LA, Berchuck A, Secord AA. Prognostic relevance of microvessel density in previously untreated, advanced-stage epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. Gynecologic Oncology 2008; 108(3 Suppl. 1):43

Weiss J, Baer M, Ambrosone CB, Blanco J, Ford L, Hutson A, Moysich KB.Polymorphisms in the glutathione S-transferase genes and treatment outcomes in acute myeloid leukemia. Proceedings of the American Association for Cancer Research Annual Meeting 2007; 48:809

Alvarez Secord A, Darcy KM, Hutson A, Huang Z, Lee PS, Jewell EL, Havrilesky LJ, Markman M, Muggia F, Murphy SK. The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study. Gynecologic Oncology 2011; 123(2):314-319

Tao MH, Marian C, Shields PG, Nie J, McCann SE, Millen A, Ambrosone C,Hutson A, Edge SB, Krishnan SS, Xie B, Winston J, Vito D, Russell M, Nochajski TH, Trevisan M, Freudenheim JL. Alcohol consumption in relation to aberrant DNA methylation in breast tumors. Alcohol (Fayetteville, N.Y.) 2011; 45(7):689-699

Wang D, Miecznikowski JC, Hutson AD. Direct density estimation of L-estimates via characteristic functions with applications. Journal of Statistical Planning and Inference 2012; 142(2):567-578

Iyer R, Fetterly G, Groman A, Hutson A, Khushalani N, Mohile S, Ashton E, Litwin A, Grande C, Tomaszewski G. Sunitinib and Transarterial Chemoembolization (TACE) for Advanced Hepatocellular Carcinoma (HCC)- Final Results of a Phase 2 Trial. European Journal of Cancer (Oxford, England : 1990) 2011; 47(Suppl. 1):S447

Dong T, Tian L, Hutson A, Xiong C. Parametric and non-parametric confidence intervals of the probability of identifying early disease stage given sensitivity to full disease and specificity with three ordinal diagnostic groups. Statistics in Medicine 2011; 30(30):3532-3545

Shan G, Ma C, Hutson AD, Wilding GE. An efficient and exact approach for detecting trends with binary endpoints. Statistics in Medicine 2012; 31(2):155-164

Yu J, Vexler A, Kim S-E, Hutson AD. Two-sample empirical likelihood ratio tests for medians in application to biomarker evaluations. Canadian Journal of Statistics 2011; 39(4):671-689

Hutson AD. An 'exact' two-group median test with an extension to censored data. Journal of Nonparametric Statistics 2007; 19(2):103-112

Hutson AD. Estimating relative rank correlation: Theory and application. Statistical Methodology 2008; 5(1):46-55

Hutson AD. A discrete-continuous mixture quantile function estimator with a practical application to phase II cancer clinical trials. Statistics in Medicine2008; 27(12):2094-2109

Hutson AD. A distribution function estimator for the difference of order statistics from two independent samples. Statistical Papers 2009; 50(1):203-208

Hutson AD, Markman M, Brady MF. A permutation test approach to phase II historical control trials. Journal of Applied Statistics 2009; 36(6):589-599

McCormack RF, Hutson A. In reply to commentary: "what are the unintended consequences of changing the diagnostic paradigm for subarachnoid hemorrhage after brain computed tomography to computed topographic angiography in place of lumbar puncture?". Academic Emergency Medicine 2010; 17(9):996-997

Mudholkar GS, Asubonteng KO, Hutson AD. Transformation of the bathtub failure rate data in reliability for using Weibull-model analysis. Statistical Methodology 2009; 6(6):622-633

Abbas A, Hutson A, Khorana A, Iyer R. Vitamin D's Role in Pathogenesis of Thromboembolism. Is This an Epiphenomenon?. American Journal of Gastroenterology 2011; 106(Suppl. 2):S55-S56

Hutson AD, Wilding GE. An examination of the relative impact of type I and type II error rates in phase II drug screening trial queues. Pharmaceutical Statistics 2012; 11(2):157-162

Wilding GE, Shan G, Hutson AD. Exact two-stage designs for phase II activity trials with rank-based endpoints. Contemporary Clinical Trials 2012; 33(2):332-341

Gibbs JF, Schlieman M, Singh P, Saxena R, Martinick M, Hutson AD, Corasanti J. A pilot study of urokinase-type plasminogen activator (uPA) overexpression in the brush cytology of patients with malignant pancreatic or biliary strictures. HPB Surgery 2009; 2009(0):805971

Stewart SH, Connors GJ, Hutson A. Ethnicity and gamma-glutamyltransferase in men and women with alcohol use disorders. Alcohol and Alcoholism (Oxford, Oxfordshire) 2007; 42(1):24-27

Hutson AD, Wilding GE. Maintaining the exchangeability assumption for a two-group permutation test in the non-randomized setting. Journal of Applied Statistics 2012; 39(7):1593-1603

Quan L, Dittmar A, Zhou Y, Hutson A, Stassen APM, Demant P. Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice. Genes, Chromosomes and Cancer 2012; 51(7):631-643

Reddy K, Ashton E, Buitrago S, Hutson A, Tennant BC, Iyer RV. Validating the woodchuck model for studying antiangiogenic therapies for human hepatocellular carcinoma (HCC) : 2012 Gastrointestinal Cancers Symposium. Journal of Clinical Oncology 2012; 30(4 Suppl.):Abstract #239