Alan Hutson, PhD, MA

Chair, Department of Biostatistics and Bioinformatics

Research Interests:

  • Clinical trial design, computational methods and order statistics

Biography

I am the Chair of Biostatistics and Bioinformatics at Roswell Park Comprehensive Cancer Center and Associate Director of the Biostatistics Shared Resource. I received my B.A. (1988) and M.A. (1990) in Statistics from the State University of New York (SUNY) at Buffalo. I then worked for Otsuka America Pharmaceuticals for two years as a biostatistician. I then received my M.A. (1993) and Ph.D. (1996) in Statistics from the University of Rochester. My Ph.D. advisor was Professor Govind Mudholkar, a world-renown researcher in Statistics and Biostatistics.
I was hired as a biostatistician at the University of Florida in 1996 as a Research Assistant Professor and worked my way to Associate Professor. I had several roles at the University of Florida including Interim Director of the Division of Biostatistics and Director of the General Clinical Research Informatics Core.
I moved to the State University of New York at Buffalo in 2002 as an Associate Professor and Chief of the Division of Biostatistics. I was the founding chair of the new Department of Biostatistics in 2003 and became a full professor in 2007.
My accomplishments as Chair included the implementation of several new undergraduate and graduate degree programs and a substantial growth in the size and quality of the department faculty and students. In 2005 I became Chair of Biostatistics (now Biostatistics and Bioinformatics) at Roswell Park, was appointed to Professor of Oncology and was the Director of the CCSG Biostatistics Shared Resource. I helped implement the new Bioinformatics Shared Resource at Roswell Park and the Biomedical Research Informatics Shared Resource. I am an Associate Editor of Communications in Statistics and is on the editorial board for Cancers. I am also a New York State NYSTAR Distinguished Professor and Fellow of the American Statistical Association.
I have membership on several data safety and monitoring boards and has served on several high-level scientific review panels. I have more than 300 peer reviewed publications and two monographs. My methodological work focuses on nonparametric methods for biostatistical applications as it pertains to statistical functionals. I have several years of experience in the design and analysis of clinical trials. Currently I am serving on SITC’s Data Sharing and Big Data Taskforce. I am also the contact MPI for the U24 Cancer Immunoprevention Network (CIP-Net): Data and Resource Coordinating Center, the Acquired Resistance to Therapy Network (ARTNet) Coordinating Center and Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Data and Resource Coordination Center. I am currently Chair of co-Chair of the CIP-Net, ARTNet and CAP-IT Steering Committees.

Positions

Roswell Park Comprehensive Cancer Center

  • Professor of Oncology
  • Chair – Department of Biostatistics and Bioinformatics

State University of New York at Buffalo

  • Research Professor

Background

Education and Training

  • 1996 - PhD - Statistics ,University of Rochester, Rochester, NY
  • 1993 - MA - Statistics, University of Rochester, Rochester, NY
  • 1990 - MA - Statistics, State University of New York at Buffalo, Buffalo, NY
  • 1988 - BA - Statistics, State University of New York at Buffalo, Buffalo, NY

Professional Memberships

  • American Statistical Association (Fellow)
  • Society for Controlled Clinical Trials, Member of the Society for Immunotherapy of Cancer (SITC)
  • American Association for Cancer Research (AACR)

Honors & Awards

  • 2013 - Inducted into Delta Omega Public Health Honor Society, Gamma Lambda Chapter (inaugural selection)
  • 2011 - Elected Fellow of the American Statistical Association
  • 2010 - UB School of Public Health and Health Professions Outstanding Senior Researcher
  • 2004 - UB School of Public Health and Health Professions Dean’s Award
  • 2001 - NYSTAR Distinguished Professor with Recognized Excellence in Bioinformatics

Publications

  Full Publications list on PubMed
  • Ambrosone, C.B., Zirpoli, G,R., Hutson, A.D., McCann, W.E., McCann, S.E., Barlow, W.E., Kelly, K.M., Cannioto, R., Sucheston-Campbell, L.E., Hershman, D.L., Unger, J.M., Moore, H.C.F., Stewart, J.A., Isaacs, C., Hobday, T.J., Salim, M., Hortobagyi, G.N., Gralow, J.R., Budd, G.T. & Albain, K.S. (2020) Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221). J Clin Oncol, 38(8): 804-814
  • Cannioto, R.A., Hutson, A., Dighe, S., McCann, W., McCann, S.E., Zirpoli, G.R., Barlow, W., Kelly, K.M., DeNysschen, C.A., Hershman, D.L., Unger, J.M., Moore, H.C.F., Stewart, J.A., Isaacs, C., Hobday, T.J., Salim, M., Hortobagyi, G.N., Gralow, J.R., Albain, K.S., Budd, G.T. & Ambrosone, C.B. (2020) Physical activity before, during and after chemotherapy for high-risk breast cancer: relationships with survival. J Natl Cancer Inst, doi: 10.1093/jnci/djaa046
  • Carlson, J.W., Kauderer, J., Hutson, A., Carter, J., Armer, J., Lockwood, S., Nolte, S., Stewart, B.R., Wenzel, L., Walker, J., Fleury, A., Bonebrake, A., Soper, J., Mathews, C., Zivanovic, O., Richards, W.E., Tan, A., Alberts, D.S. & Barakat, R.R. (2020) GOG 244-The lymphedema and gynecologic cancer (LEG) study: Incidence and risk factors in newly diagnosed patients. Gynecol Oncol, 156(2): 467-474
  • Shaurova, T., Dy, G.K., Battaglia, S., Hutson, A., Zhang, L., Zhang, Y., Lovly, C.M., Seshadri, M., Goodrich, D.W., Johnson, C.S. & Hershberger, P.A. (2020) Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance. Cancers (Basel), 12(3): 675
  • Chen, G.L., Hahn, T., Wilding, G.E., Groman, A., Hutson, A., Zhang, Y., Khan, U., Liu, H., Ross, M., Bambach, B., Higman, M., Neppalli, V., Sait, S., Block, A.W., Wallace, P.K., Singh, A.K. &  McCarthy, P.L. (2019) Reduced intensity conditioning with fludarabine, melphalan, and total body irradiation for allogeneic hematopoietic cell transplantation: the effect of increasing melphalan dose on underlying disease and toxicity. Biology of Blood and Marrow Transplantation, 25: 689-698
  • Kalathil, S., Hutson, A., Barbi, J., Iyer, R. & Thanavala, Y. (2019) Augmentation of IFN-γ+ CD8+ T cell responses correlates with survival of Hepatocellular Carcinoma (HCC) patients on sorafenib therapy. JCI Insights, 4: e130116
  • Hutson, A.D. (2019) A robust Pearson correlation test for a general point null using a surrogate bootstrap distribution. PLOS One, 14(5): e0216287
  • Hutson, A.D. & Vexler, A. (2018) A Cautionary Note on Beta Families of Distributions and the Aliases Within. The American Statistician, 72: 121-129
  • Wentink, M.Q., Verheul, H.M.W., Pal, S.K., George, S., Voortman, J., Danchaivijitr, P., Adelaiye, R., Poslinski, D., Groman, A., Hutson, A. & Pili, R. (2018)  Phase I Study of Dalteparin in Combination With Sunitinib in Patients With Metastatic Clear Cell Renal Carcinoma. Clinical Genitourinary Cancer, 16: e1-e9
  • Dong, T., Attwood, K., Hutson, A., Liu, S. & Tian, L. (2017) A new diagnostic accuracy measure and cut-point selection criterion. Statistical Methods in Medical Research, 26: 2832-2852
  • Pili, R., Quinn, D.I., Hammers. H., Monk, J.P., George, S., Dorff, T., Olencki, T., Shen, L., Orillion, A.R., Lamonica, D., Fragomeni, R.A.S., Szabo, Z., Hutson, A.D., Groman, A., Perkins, S.M., Piekarz, R.L. & Carducci, M.A. (2017) Immunomodulation by entinostat in renal cell carcinoma patients receiving high dose interleukin 2: a multicenter, single-arm, phase 1/2 trial (NCI-CTEP#7870). Clinical Cancer Research, 23: 7199-720
  • Fenstermaker, R.A., Ciesielski, M.J., Qiu, J., Yang, N., Frank, C.L., Lee, K.P., Mechtler, L.R., Belal, A., Ahluwalia, M.S. & Hutson, A.D.(2016) Clinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma. Cancer Immunology Immunotherapy, 65(11): 1339-1352
  • Hutson, A.D. (2016) Nonparametric rank based estimation of bivariate densities given censored data conditional on marginal probabilities. Journal of Statistical Distributions and Applications, 3:9. doi.org/10.1186/s40488-016-0047-y
  • Shan, G., Wilding, G.E., Hutson, A.D. & Gerstenberger, S. (2016) Optimal adaptive two-stage designs for early phase II clinical trials. Statistics in Medicine, 35: 1257-1266
  • Chandrasekhar, R., Shi, Y., Hutson, A.D. & Wilding, G.E. (2015) Likelihood-based inferences about the mean area under a longitudinal curve in the presence of observations subject to limits of detection. Journal of Biopharmaceutical Statistics, 14: 252-261
  • Hutson, A.D., Wilding, G.E., Mashtare, T.L. & Vexler, A. (2015) Measures of Biomarker Dependence Using a Copula Based Multivariate Epsilon-Skew-Normal Family of Distributions. Journal of Applied Statistics, 42: 2734-2753
  • Wei, L., Wang, D. & Hutson, A.D. (2015) An Investigation of Quantile Function Estimators Relative to Quantile Confidence Interval Coverage. Communications in Statistics – Theory and Methods, 44: 2107-2135
  • Fallavollita, J.A., Heavey, B.M., Luisi, A.J. Jr., Michalek, S.M., Baldwa, S., Mashtare, T.L., Jr., Hutson, A.D., Dekemp, R.A., Haka, M.S., Sajjad, M., Cimato, T.R., Curtis, A.B, Cain, M.E. & Canty, J.M., Jr. (2014). Regional Myocardial Sympathetic Denervation Predicts the Risk of Sudden Cardiac Arrest in Ischemic Cardiomyopathy. Journal of the American College of Cardiology, 63: 141-149
  • Shan, G., Ma, C.X., Hutson A.D. & Wilding, G.E. (2013) Randomized Two-Stage Phase II Clinical Trial Designs Based on Barnard’s Exact Test. Journal of Biopharmaceutical Statistics, 23: 1081-1090
  • Wang, D., Miecznikowski, J.C. & Hutson, A.D. (2012) Direct density estimation of L-estimates via characteristic functions with applications. Journal of Statistical Planning and Inference, 142: 5567-578
  • Wilding, G.E., Shan, G. & Hutson, A.D. (2012) Exact two-stage designs for phase II activity trials with rank-based endpoints. Contemporary Clinical Trials, 33: 332-341