Specializing In:
Pre-clinical research Biomedical research projectsResearch Interests:
Pre-clinical models Maintenance of pre-clinical immunocompromised models (SCIDs and NSGs) Maintenance of models to support the impact of aging studies Pre-clinical models of liver cancerAbout Sandra Sexton
Biography:
I earned a Doctorate in Veterinary Medicine in 1991 from the University of Agricultural Sciences in Bogotá, Colombia. After working in private practice and then relocating to the United States, I obtained the degree certification in Veterinary Medicine and Surgery and went on to completing a postdoctoral residency in Laboratory Animal Medicine from the State University of NY at Buffalo, Division of Comparative Medicine.
I joined Roswell Park Comprehensive Cancer Center in 2003 as a Research Affiliate and Post-doctoral veterinary resident and was then appointed as Institute Veterinarian of the Laboratory Animal Shared Resource (LASR). I was promoted to Facility Director and Attending Veterinarian in 2006. I obtained the Board Certification as a Diplomate of the American College of Laboratory Animal Medicine in 2013.
As COSR Director and Attending veterinarian, I provide support to scientists in all CCSG Programs with diverse experimental objectives, and operational leadership in the resource to have a care program that include provision of appropriate facilities, personnel, and equipment to assure compliance with all regulatory requirements and maintain AAALAC International accreditation.
Positions
- Associate Professor of Oncology
- Facility Director and Attending Veterinarian, Comparative Oncology Shared Resource
- Department of Comparative Oncology Resources
Background
Education and Training:
- 1991 - DVM - University of Agricultural Sciences, Bogotá, Colombia
Residency:
- 2005 - Comparative Oncology, State University of New York at Buffalo and Roswell Park Comprehensive Cancer Center
Board Certification:
- 2013 - Diplomate, American College of Laboratory Animal Medicine
- 2006 - USA Veterinary Medicine and Surgery License
Professional Memberships:
- American Association of Laboratory Animal Science
- Buffalo Academy of Veterinary Medicine
Honors & Awards:
- 2018 - Minority and Women Emerging Entrepreneurs Program, second place, Place Protégé of the Year for Marmota-Tek
Publications
Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, Li J, Turowski SG, Sexton S (ZY), Sait SJ, Singh PK, Wang J (DT), Maitra A, Kalinski P (TII), DePinho RA, Wang H, Liao W, Abrams SI (TII), Segal BH (TII), Dey P (TII). Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell. 2022 FEB 14; 40(2):153-167.e11. DOI: 10.1016/j.ccell.2022.01.003. 2022 Feb 3. PubMed PMID: 35120601; PMCID: PMC8847236.
Baysal BE, Alahmari AA, Rodrick TC, Tabaczynski D, Curtin L, Seshadri M (CSB), Jones DR, Sexton S (ZY). Succinate dehydrogenase inversely regulates red cell distribution width and healthy life span in chronically hypoxic mice. JCI Insight. 2022 SEP 08; 7(17). DOI: 10.1172/jci.insight.158737. 2022 Sep 8. PubMed PMID: 35881479; PMCID: PMC9536274.
Hylander BL, Repasky EA (CSB), Sexton S (ZY). Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility. Animals (Basel). 2022 FEB 03; 12(3). DOI: 10.3390/ani12030371. 2022 Feb 3. PubMed PMID: 35158694; PMCID: PMC8833596.
Yang L, Bhattacharya A, Li Y, Sexton S (ZY), Ling X, Li F (DT), Zhang Y. Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer. J. Exp. Clin. Cancer Res.. 2022 JUN 02; 41(1):184. DOI: 10.1186/s13046-022-02389-z. 2022 Jun 2. PubMed PMID: 35650607; PMCID: PMC9161494.
Sonkawade SD, Pokharel S (CSBT), Karthikeyan B, Kim M (CSBT), Xu S, Kc K, Sexton S (ZY), Catalfamo K, Spernyak JA (CSBT), Sharma UC. Small Endogeneous Peptide Mitigates Myocardial Remodeling in a Mouse Model of Cardioselective Galectin-3 Overexpression. Circ Heart Fail. 2021 SEP 01; 14(9):e008510. DOI: 10.1161/CIRCHEARTFAILURE.121.008510. 2021 Aug 20. PubMed PMID: 34415177; PMCID: PMC8458256.
Rajab Bolookat E, Malhotra H, Rich LJ, Sexton S (ZY), Curtin L, Spernyak JA (CSBT), Singh AK (CSBT), Seshadri M (CSBT). Development and Validation of a Clinically Relevant Workflow for MR-Guided Volumetric Arc Therapy in a Rabbit Model of Head and Neck Cancer. Cancers (Basel). 2020 MAR 01; 12(3). DOI: 10.3390/cancers12030572. 2020 Mar 1. PubMed PMID: 32121562; PMCID: PMC7139631.
Kim M (CSBT), Powers CA, Curtin LI, Fisher DT, Sexton S (ZY), Gurova KV (CSBT), Skitzki JJ (TII), Iyer RV (DT). A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks. J. Surg. Res.. 2020 JUL 01; 251:126-136. DOI: 10.1016/j.jss.2020.02.002. 2020 Mar 3. PubMed PMID: 32143057; PMCID: PMC7830851.
Book – Chapter 8 - Co-author of “The Laboratory Woodchuck (Marmota monax),” a chapter within Laboratory Animal Medicine (American College of Laboratory Animal Medicine Series, Third Edition, 2015).