Targeting the tumor immune microenvironment to improve ovarian and prostate cancer treatment
We believe that understanding of oncogenic signaling pathways in tumor cells and their role in modulating immunosuppressive tumor microenvironment will pave the way to improved strategies for cancer treatment.
Meet the PI
Exploring the interactions between cancer cells and the host immune system
The tumor immune microenvironment plays a central role in supporting tumor progression, metastasis, and resistance to therapies. Our research focuses on how the oncogenic signals in tumor cells foster protumor environments to evade immune surveillance and promote tumorigenesis and therapeutic resistance.
The epigenetic regulation of immune cells in the tumor microenvironment significantly contributes to therapeutic resistance and tumor progression. We are developing novel therapies for ovarian and prostate cancer by targeting both tumor and tumor immune microenvironment.
Funding sources
Combined inhibition of ATR and p110β as Therapy in PTEN-deficient Prostate Cancer
- Funded by: National Cancer Institute (2024)
- Award: R21 Exploratory/Developmental Research Grant
- Role: Principal Investigator
The immunomodulatory function of Cyclin E1 in ovarian cancer and therapeutic targeting
- Funded by: National Cancer Institute (2024)
- Award: R37 Method to Extend Research in Time (MERIT) Award
- Role: Principal Investigator
Targeting therapeutic resistance to PARP inhibition in ovarian cancer
- Funded by: Ovarian Cancer Research Alliance (2021)
- Award: Early Career Investigator Grant
- Role: Principal Investigator
Join our team!
The Ding Lab is looking for a postdoctoral fellow in cancer biology and immunology. A multidisciplinary approach is applied to study the essential regulators of immunosuppression in tumor progression, metastasis, and therapeutic resistance in ovarian and prostate cancer.
Faculty affiliations
Connect with the Ding Lab
Email: Liya.Ding@RoswellPark.org
Office location: Center for Genetics & Pharmacology (CGP) L5-310
Lab Location: Center for Genetics & Pharmacology (CGP) L5-111
Department of Immunology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263