Targeting the epigenome in sarcomas and other pediatric, adolescent and young adult cancers
By studying the human genome, scientists like Joyce Ohm, PhD, can modify cell behaviors and – in the case of some cancers – turn off activity in cells that lead to tumors and tumor growth.
In her lab at Roswell Park, Dr. Ohm’s team is investigating how genetic and environmental factors reprogram genes to turn off the cancer and tumor cell growth for pediatric, adolescent and young adult (AYA) cancer patients.
Meet the PI
Research focus: Cancer epigenetics
My laboratory is actively investigating how both genetic and environmental determinants may reprogram the epigenome and contribute to tumor initiation and progression.
Our research projects include:
- STAG2 modulates environmental toxicant exposures and epigenomic heterogeneity
- Novel therapeutics for Ewing sarcoma
- Novel 7SK non-coding RNA fusions in soft tissue sarcomas to tumorigenesis,
- Environmental toxins and stem cell epigenetic remodeling
Join the Ohm Lab team!
We’re currently recruiting master’s, PhD, and MD/PhD students – email Dr. Ohm for details, then learn more about advancing your career at Roswell Park.
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Department of Cancer Genetics and Genomics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263