Understanding epigenetic regulations in cancer progression and metastasis
Our laboratory focuses on the molecular dissection of various epigenetic modifications in tumorigenesis and metastatic progression. Our long-term goals are to identify novel diagnostic and therapeutic targets and to develop more effective therapeutic strategies.
We employ a wide range of biochemical and molecular approaches as well as genetically engineered mouse models to investigate the functional importance of different chromatin modifying enzymes and the catalyzed modifications that regulate chromatin dynamics and potentiate malignancy.
Histone methyltransferase SETDB1 promotes non-small cell lung cancer metastasis
E3-Independent K867-monoubiquitination augments enzymatic activity of SETDB1
Methyl-H3K9 binding protein MPP8 promotes TSG silencing and EMT
Selected publications
You’ll find articles from the Abel Lab in numerous high-impact journals.
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Department of Pharmacology and Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263