Cancer Cell, February 2022
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
- Oncogenic KRASG12D upregulates IL-33 to promote type 2 immunity in PDAC
- Intratumoral mycobiome enhances cancer cell secretion of IL-33
- Secreted IL-33 recruits and activates TH2 and ILC2 cells in the PDAC TME
- Genetic deletion of IL-33 or anti-fungal treatment causes PDAC tumor regression
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Contact the Dey Lab
Email: Prasenjit.Dey@RoswellPark.org
Phone: 716-845-1300, x5269
Office location: Center for Genetics & Pharmacology (CGP) L5-307
Lab Location: Center for Genetics & Pharmacology (CGP) L15-115
Department of Immunology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263