Ellis G. Levine, MD

Specialty: Medical Oncology
Department of Medicine
The Hope Ilona Gottlieb Endowed Chair in Breast Cancer Translational Research

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Locations

Roswell Park Main Campus
1-800-ROSWELL (1-800-767-9355)

Dr. Levine is a Buffalo Spree Top Doctor! Top Doctors 2025 See all of our physicians who made this year's list.

Cancers Treated:

Bladder Breast Penile Prostate Testicular Urethral

Research Interests:

  • Novel therapies for breast and urothelial cancer

Positions

Roswell Park Comprehensive Cancer Center

  • Professor of Oncology
  • Hematology/Medical Oncology Fellowship Program Director
  • Department of Medicine
  • The Hope Ilona Gottlieb Endowed Chair in Breast Cancer Translational Research

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo

  • Professor of Medicine
  • Hematology/Medical Oncology Fellowship Program Director

Background

Education and Training

  • MD - University of Pittsburgh, Pittsburgh, PA

Residency

  • University of Minnesota, Minneapolis, MN

Fellowship

  • University of Minnesota, Minneapolis, MN

Board Certification

  • Internal Medicine, American Board of Internal Medicine
  • Medical Oncology, American Board of Internal Medicine

Honors & Awards

  • 2005-2023 - America’s Top Doctors
  • 2018 - Susan G. Komen Hope Award for Upstate New York
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
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Testing Low Dose Tamoxifen for Invasive Breast Cancer, the (LoTam) Trial
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Home-based Respiratory Muscle Training for Minimizing Side Effects in Patients Undergoing Treatment for Breast Cancer
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Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
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Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
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Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)
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Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial
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Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial
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Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial
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Abemaciclib and Endocrine Therapy in Older Patients with Breast Cancer.
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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
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Clinical Trials

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
Learn More
Testing Low Dose Tamoxifen for Invasive Breast Cancer, the (LoTam) Trial
Learn More
Home-based Respiratory Muscle Training for Minimizing Side Effects in Patients Undergoing Treatment for Breast Cancer
Learn More
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Learn More
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
Learn More
Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)
Learn More
Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial
Learn More
Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial
Learn More
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial
Learn More
Abemaciclib and Endocrine Therapy in Older Patients with Breast Cancer.
Learn More
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Learn More
ER-positive breast cancer: Edith’s story Triple-positive breast cancer: Jennifer’s story Stage 2 male breast cancer: Jim’s story Breast cancer at 32: Sheila's story Breast Cancer in Young Women: Family History Is the Best Indicator of Risk Can Breast Cancer Return After a Double Mastectomy? Prostate Cancer Survivor: Denny's Story Breast Cancer in Men: Owen’s Story What Happens If My Cancer Treatment Stops Working? How Research Saved My Life Detours and Delays, Then a New Route to Happiness What Happens When Pregnancy and Cancer Collide?

Featured on CancerTalk

ER-positive breast cancer: Edith’s story
Edith Lazatin rings the victory bell, holding a bouquet of flowers, while Dr. Kazuaki Takabe cheers her on.
Triple-positive breast cancer: Jennifer’s story
Photo of Jennifer
Stage 2 male breast cancer: Jim’s story
A man crouches down by his last name, written in chalk, outside Roswell Park Comprehensive Cancer Center, during the week leading up to the Ride for Roswell.

Showing all3 of 12

Publications

  Full Publications list on PubMed

Gandhi S, Opyrchal M, Grimm MJ, Slomba RT, Kokolus KM, Witkiewicz A, Attwood KM, Groman A, Williams l, Tarquini ML, Wallace PK, Soh KT, Minderman H, Mcguire O, O’Connor TL, Early AP, Levine EG, Kalinski P (2022) Systemic IFN-a/TLR3-Ligand Combination Reprograms Local Microenvironments of Breast Cancer Lesions for Selective CTL Influx. Journal for ImmunoTherapy of Cancer 2023;11:e007381. doi: 10.1136/jitc-2023-007381

Ademuyiwa FO, Northfelt DW, O'Connor T, Levine E, Luo J, Tao Y, Hoog J, Laury ML, Summa T, Hammerschmidt T, Guo Z, Frith A, Weilbaecher K, Opyrchal M, Aft R, Clifton K, Suresh R, Bagegni N, Hagemann IS, Iglesia MD, Ma CX. A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN). NPJ Breast Cancer. 2023 Jan 6;9(1):1. doi: 10.1038/s41523-022-00504-z. PMID: 36609389; PMCID: PMC9822956.

Abraham A, Barcenas CH, Bleicher RJ, Cohen AL, Javid SH, Levine EG, Lin NU, Moy B, Niland JC, Wolff AC, Hassett MJ, Asad S, Stover DG. Clinicopathologic and sociodemographic factors associated with late relapse triple negative breast cancer in a multivariable logistic model: A multi-institution cohort study. Breast. 2023 Feb;67:89-93. doi: 10.1016/j.breast.2023.01.004. Epub 2023 Jan 17. PMID: 36681001.

Witkiewicz AK, Schultz E, Wang J, Hamilton D, Levine E, O'Connor T, Knudsen ES. Determinants of response to CDK4/6 inhibitors in the real-world setting. NPJ Precis Oncol. 2023 Sep 13;7(1):90. doi: 10.1038/s41698-023-00438-0. PMID: 37704753; PMCID: PMC10499925.

Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer. Gandhi S, Slomba RT, Janes C, Fitzpatrick V, Miller J, Attwood K, Ioannou G, Ozbey S, De Souza I, Roudko V, Kumar P, Kalathil S, Kokolus KM, Wang J, Cortes Gomez E, Takabe K, Edge S, Young J, Cappuccino H, Opyrchal M, O'Connor T, Levine EG, Gnjatic S, Kalinski P. J Immunother Cancer. 2024 Nov 14;12(11):e010058. doi: 10.1136/jitc-2024-010058. PMID: 39542655 Free PMC article. Clinical Trial.