You’ll find research from the Das Lab in numerous influential cancer research publications.
Therapeutic Role of Tamoxifen for Triple-Negative Breast Cancer: Leveraging the Interaction Between ERβ and Mutant p53
- Journal: The Oncologist, February 2023
- Authors: Scarpetti L, et al.
- Citation: Oncologist. 2023 Feb 11;. doi: 10.1093/oncolo/oyac281
Estrogen receptor-beta2 (ERβ2)-mutant p53-FOXM1 axis is an important driver of proliferation, chemoresistance, and disease progression in high grade serous ovarian cancer (HGSOC).
- Journal: Cells, 2022
- Authors: Oturkar CC, Das GM. et al
- Citation: Cancers, 14: 1120, doi: 10.3390/cancers14051120
TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer
- Journal: Journal of the National Cancer Institute, November 2019
- Authors: Mukhopadhyay UK, et al.
- Citation: J Natl Cancer Inst. 2019 Nov 1;111(11):1202-1215. doi: 10.1093/jnci/djz051
- Scarpetti, L., Oturkar, C.C., Kuter, I., Juric, D., Shellocki, M., Malvarosa, G., Post, K., Isakoff, S., Wang, N., Nahedi, B., Oh, K., Das, G.M*., Bardia, A*. (*Co-senior and Co-corresponding authors) (2023). Therapeutic role of tamoxifen for triple negative breast cancer: leveraging the interaction between estrogen receptor-beta (ERb) and mutant p53. The Oncologist, 2023, 28,358-353.
- Liu S, et al. A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer. Elife. 2017 Aug 18;6. doi: 10.7554/eLife.28482.
- Ramakrishnan S, et al. HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. BMC Cancer. 2016 Aug 9;16:617. doi: 10.1186/s12885-016-2604-7.
- Swetzig WM, Wang J, Das GM. Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget. 2016 Mar 29;7(13):16049-69. doi: 10.18632/oncotarget.7533.
- Putluri N, et al. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 2014 May;16(5):390-402. doi: 10.1016/j.neo.2014.05.007
- Wickramasekera NT, Das GM. Tumor suppressor p53 and estrogen receptors in nuclear-mitochondrial communication. Mitochondrion. 2014 May;16:26-37. doi: 10.1016/j.mito.2013.10.002. Epub 2013 Oct 29. Review.
- Tang L, et al. Transcriptional inhibition of p21WAF1/CIP1 gene (CDKN1) expression by survivin is at least partially p53-dependent: evidence for survivin acting as a transcription factor or co-factor. Biochem Biophys Res Commun. 2012 May 4;421(2):249-254. doi: 10.1016/j.bbrc.2012.03.147. Epub 2012 Apr 6.
- Nayvelt I, et al. A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells. Amino Acids. 2012 Feb;42(2-3):899-911. doi: 10.1007/s00726-011-1005-0. Epub 2011 Aug 10.
- Liu W, et al. Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. PLoS One. 2011;6(12):e29466. doi: 10.1371/journal.pone.0029466. Epub 2011 Dec 22.
Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications
- Journal: Cells, 2019
- Authors: Gandhi N, Das GM.
- Citation: Cells. 2019 Jan 26;8(2). doi: 10.3390/cells8020089
Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation
- Journal: Proceedings of the National Academy of Science, August 2010
- Authors: Konduri SD, Medisetty R, Liu W, Kaipparettu BA, Srivastava P, Brauch H, Fritz P, Swetzig WM, Gardner AE, Khan SA, Das GM.
- Citation: Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15081-6. doi: 10.1073/pnas.1009575107. Epub 2010 Aug 9
- Liu W, et al. Disruption of estrogen receptor alpha-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy. Breast Cancer Res Treat. 2009 May;115(1):43-50. doi: 10.1007/s10549-008-0044-z. Epub 2008 May 15.
- John S, et al. Regulation of estrogenic effects by beclin 1 in breast cancer cells. Cancer Res. 2008 Oct 1;68(19):7855-63. doi: 10.1158/0008-5472.CAN-07-5875.
- Kaipparettu, et al. Estrogen-mediated downregulation of CD24 in breast cancer cells. Int J Cancer. 2008 Jul 1;123(1):66-72. doi: 10.1002/ijc.23480.
- Sayeed A, et al. Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer Res. 2007 Aug 15;67(16):7746-55. doi: 10.1158/0008-5472.CAN-06-3724.
- Liu W, et al. Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function. J Biol Chem. 2006 Apr 14;281(15):9837-40. doi: 10.1074/jbc.C600001200. Epub 2006 Feb 9.
- Desouki MM, et al. Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol Ther. 2005 Dec;4(12):1367-73. doi: 10.4161/cbt.4.12.2233. Epub 2005 Dec 12.
- Narayan S, et al. Cigarette smoke condensate-induced transformation of normal human breast epithelial cells in vitro. Oncogene. 2004 Aug 5;23(35):5880-9. doi: 10.1038/sj.onc.1207792.
- Nayak BK, Das GM. Stabilization of p53 and transactivation of its target genes in response to replication blockade. Oncogene. 2002 Oct 17;21(47):7226-9. doi: 10.1038/sj.onc.1205889.
Contact the Das Lab
Email: Gokul.Das@RoswellPark.org
Phone: 716-845-8542
Department of Pharmacology and Therapeutics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263