You’ll find research from the Bakin Lab in Cell Reports Medicine, Communications Biology, Cancer Research Communications, International Journal of Cancer, Scientific Reports, Nature Methods, and other influential publications.
A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
- Journal: Cell Reports Medicine, March 2024
- Authors: Alruwaili MM, Zonneville J, Naranjo MN, Serio H, Melendy T, Straubinger RM, Gillard B, Foster BA, Rajan P, Attwood K, Chatley S, Iyer R, Fountzilas C, Bakin AV.
- Citation: Cell Rep Med. 2024 Mar 19;5(3):101434. doi: 10.1016/j.xcrm.2024.101434.
Selective therapeutic strategy for p53-deficient cancer by targeting dysregulation in DNA repair
- Journal: Communications Biology, July 2021
- Authors: Zonneville J, Wang M, Alruwaili MM, Smith B, Melnick M, Eng KH, Melendy T, Park BH, Iyer R, Fountzilas C, Bakin AV.
- Citation: Commun Biol. 2021 Jul 12;4(1):862.
- Xing Z, et al. Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome. Hum Mol Genet. 2023 Jun 19;32(13):2205-2218. doi: 10.1093/hmg/ddad056.
- Martin JC, et al. WEE1 inhibition augments CDC7 (DDK) inhibitor-induced cell death in Ewing sarcoma by forcing premature mitotic entry and mitotic catastrophe. Cancer Res Commun. 2022 Jun;2(6):471-482. doi: 10.1158/2767-9764.crc-22-0130.
- Zonneville J, et al. Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis. Int J Cancer. 2020 Oct 15;147(8):2279-2292. doi: 10.1002/ijc.33050.
- Zonneville J, et al. TAK1 signaling regulates p53 through a mechanism involving ribosomal stress. Sci Rep. 2020 Feb 13;10(1):2517. doi: 10.1038/s41598-020-59340-5.
- Fink EE, et al. XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response. Cell Rep. 2018 Oct 2;25(1):212-223.e4. doi: 10.1016/j.celrep.2018.09.013.
- Zonneville J, et al. TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association. BMC Cancer. 2018 Jun 19;18(1):670. doi: 10.1186/s12885-018-4587-z.
Connect with the Bakin Lab
Department of Cancer Genetics & Genomics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263