Check out the latest published research papers from the Rosario Lab.
Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers
- Journal: International Journal of Molecular Science, June 2023
- Authors: Rosario SR, et al.
- Citation: Int J Mol Sci. 2023 Jun 29;24(13):10847. doi: 10.3390/ijms241310847.
- Smith R Jr, et al. Immunoprofiling bronchoalveolar lavage cells reveals multifaceted smoking-associated immune dysfunction. ERJ Open Res. 2023 Jun 19;9(3):00688-2022. doi: 10.1183/23120541.00688-2022. PMID: 37342091; PMCID: PMC10277872.
- Boucher Y, et al. Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer. Clin Cancer Res. 2023 Apr 14;29(8):1605-1619. doi: 10.1158/1078-0432.CCR-22-1630. PMID: 36749873; PMCID: PMC10106451.
- Grant SR, et al. HotSPOT: A Computational Tool to Design Targeted Sequencing Panels to Assess Early Photocarcinogenesis. Cancers (Basel). 2023 Mar 5;15(5):1612. doi: 10.3390/cancers15051612. PMID: 36900402; PMCID: PMC10001346.
- Rosario SR, et al. Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment. Cancer Metab. 2022 Oct 26;10(1):17. doi: 10.1186/s40170-022-00292-x. PMID: 36289552; PMCID: PMC9598035.
- Dai T, et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756. PMID: 36476868; PMCID: PMC9807018.
- Torres-Estay V, et al. The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells. Cancers (Basel). 2022 Sep 29;14(19):4750. doi: 10.3390/cancers14194750. PMID: 36230673; PMCID: PMC9563990.
- Omole EB, et al. Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers. Cancers (Basel). 2022 Sep 28;14(19):4724. doi: 10.3390/cancers14194724. PMID: 36230652; PMCID: PMC9562635.
- Zhu Q, et al. Whole-Genome Sequencing Identifies PPARGC1A as a Putative Modifier of Cancer Risk in BRCA1/2 Mutation Carriers. Cancers (Basel). 2022 May 10;14(10):2350. doi: 10.3390/cancers14102350. PMID: 35625955; PMCID: PMC9139302.
Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses
- Journal: Science Translation Medicine, March 2022
- Authors: Odunsi K, et al.
- Citation: Sci Transl Med. 2022 Mar 16;14(636):eabg8402. doi: 10.1126/scitranslmed.abg8402.
- Long MD, et al. Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer. Cell Rep. 2021 Dec 14;37(11):110109. doi: 10.1016/j.celrep.2021.110109. PMID: 34910907; PMCID: PMC8889623.
- Knudsen ES, et al. Pan-cancer molecular analysis of the RB tumor suppressor pathway. Commun Biol. 2020 Apr 2;3(1):158. doi: 10.1038/s42003-020-0873-9. PMID: 32242058; PMCID: PMC7118159.
- Affronti HC, et al. Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy. Nat Commun. 2020 Jan 7;11(1):52. doi: 10.1038/s41467-019-13950-4. PMID: 31911608; PMCID: PMC6946658.
- Hillman JC, et al. BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14. Mol Cancer Res. 2019 Oct;17(10):2051-2062. doi: 10.1158/1541-7786.MCR-19-0310. Epub 2019 Jul 10. PMID: 31292201; PMCID: PMC6943826.
- Long MD, et al. The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression. Oncogene. 2019 Jan;38(3):421-444. doi: 10.1038/s41388-018-0450-6. Epub 2018 Aug 17. PMID: 30120411; PMCID: PMC6336686.
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas
- Journal: Nature Communications, December 2018
- Authors: Rosario SR, et al.
- Citation: Nat Commun. 2018 Dec 14;9(1):5330. doi: 10.1038/s41467-018-07232-8.
Connect with the Rosario Lab
Email: Spencer.Rosario@RoswellPark.org
Phone: 716-845-1300 ext. 6271
Department of Biostatistics and Bioinformatics
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263