Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression
- Journal: iScience, February 2024
- Authors: Tzetzo SL, Kramer ED, Mohammadpour H, Kim M, Rosario SR, Yu H, Dolan MR, Oturkar CC, Morreale BG, Bogner PN, Stablewski AB, Benavides FJ, Brackett CM, Ebos JML, Das GM, Opyrchal M, Nemeth MJ, Evans SS, Abrams SI
- Citation: iScience. 2024 Feb 10;27(3):109187. doi: 10.1016/j.isci.2024.109187.
A Bacterial and Ganglioside-based Nanoparticle Initiates Reprogramming of Macrophages and Promotes Antitumor Phenotypes
- Journal: The Journal of Immunology, February 2024
- Authors: Alvarez-Arzola R, Oliver L, Messmer MM, Twum DYF, Lee KP, Muhitch JB, Mesa C, Abrams SI.
- Citation: J Immunol. 2024 Feb 1;212(3):475-486. doi: 10.4049/jimmunol.2300256. PMID: 38117752.
- Zhou S, et al. Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen. Cancer Res Commun. 2024 Apr 2;4(4):958-969. doi: 10.1158/2767-9764.CRC-23-0384. PMID: 38506662; PMCID: PMC10986479.
- Martin JC, et al. Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer. Sci Rep. 2024 Mar 8;14(1):5731. doi: 10.1038/s41598-024-54732-3. PMID: 38459088; PMCID: PMC10923803.
- Zhang L, et al. Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid-derived suppressor cells. FASEB J. 2024 Jan;38(1):e23338. doi: 10.1096/fj.202301703R. PMID: 38038723.
- McGray AJR, et al. BiTE secretion by adoptively transferred stem-like T cells improves FRα+ ovarian cancer control. J Immunother Cancer. 2023 Jun;11(6):e006863. doi: 10.1136/jitc-2023-006863. Epub 2023 Jun 23. PMID: 37647218; PMCID: PMC10314690.
β-Catenin signaling in alveolar macrophages enhances lung metastasis through a TNF-dependent mechanism
- Journal: JCI Insight, April 2023
- Authors: Kramer ED, Tzetzo SL, Colligan SH, Hensen ML, Brackett CM, Clausen BE, Taketo MM, Abrams SI
- Citation: JCI Insight. 2023 Apr 24;8(8):e160978. doi: 10.1172/jci.insight.160978.
Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression
- Journal: Journal of Clinical Investigation, December 2022
- Authors: Colligan SH, Amitrano AM, Zollo RA, Peresie J, Kramer ED, Morreale B, Barbi J, Singh PK, Yu H, Wang J, Opyrchal M, Sykes DB, Nemeth MJ, Abrams SI.
- Citation: J Clin Invest. 2022 Dec 1;132(23):e158661. doi: 10.1172/JCI158661.
- Dai T, et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756. PMID: 36476868; PMCID: PMC9807018.
- Shen H, et al. Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism. Cancer Gene Ther. 2022 Nov;29(11):1791-1800. doi: 10.1038/s41417-022-00502-0. Epub 2022 Jul 15. PMID: 35840667; PMCID: PMC9663307.
- Kwack KH, et al. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells. Front Immunol. 2022 Oct 3;13:1002163. doi: 10.3389/fimmu.2022.1002163. PMID: 36263047; PMCID: PMC9573970.
Mitigating the prevalence and function of myeloid-derived suppressor cells by redirecting myeloid differentiation using a novel immune modulator
- Journal: Journal for ImmunoTherapy of Cancer, September 2022
- Authors: Oliver L, Alvarez R, Diaz R, Valdés A, Colligan SH, Nemeth MJ, Twum DYF, Fernández A, Fernández-Medina O, Carlson LM, Yu H, Eng KH, Hensen ML, Rábade-Chediak ML, Fernández LE, Lee KP, Perez L, Muhitch JB, Mesa C, Abrams SI.
- Citation: J Immunother Cancer. 2022 Sep;10(9):e004710. doi: 10.1136/jitc-2022-004710.
- Papadas A, et al. Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment. Cell Rep. 2022 Aug 16;40(7):111201. doi: 10.1016/j.celrep.2022.111201. PMID: 35977482; PMCID: PMC9402878.
- He X, et al. An In Vivo Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity. Cancer Immunol Res. 2022 Mar 1;10(3):314-326. doi: 10.1158/2326-6066.CIR-21-0332. PMID: 34992135; PMCID: PMC8898291.
- He X, et al. Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model. J Immunother Cancer. 2021 Dec;9(12):e003101. doi: 10.1136/jitc-2021-003101. PMID: 34862254; PMCID: PMC8647534.
- Yokoi T, et al. Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer. Sci Rep. 2021 Nov 9;11(1):21992. doi: 10.1038/s41598-021-01455-4. PMID: 34754037; PMCID: PMC8578367.
Connect with the Abrams Lab
Department of Immunology
Roswell Park Comprehensive Cancer Center
Elm and Carlton Streets
Buffalo, NY 14263