Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine
- Journal: Thorax, September 2023
- Authors: Bhat TA, Kalathil SG, Goniewicz ML, Hutson A, Thanavala Y
- Citation: Thorax. 2023 Sep;78(9):922-932
An Animal Model of Inhaled Vitamin E Acetate and EVALI-like Lung Injury
- Journal: New England Journal of Medicine, March 2020
- Authors: Bhat TA, Kalathil SG, Bogner PN, Blount BC, Goniewicz ML, Thanavala YM.
- Citation: N Engl J Med. 2020 Mar 19;382(12):1175-1177
The observation that BAL fluid from EVALI patients contained vitamin E acetate was an important step toward understanding the causes of recent vaping-related lung injuries. This finding that animals exposed to vitamin E acetate aerosols demonstrate many of the biological characteristics of EVALI patients reinforces that vitamin E acetate should not be added to vaping products. This potential animal model of EVALI is critical to further investigate pathological mechanisms and develop therapies.James Kiley, PhD, Director of the Division of Lung Diseases at the National Heart, Lung and Blood Institute (NHLBI)
- Bhat TA, Kalathil SG, Leigh N, Hutson A, Goniewicz ML, Thanavala YM. Do alternative tobacco products induce less adverse respiratory risk than cigarettes? Respir Res. 2023 Oct 31;24(1):261.
- Bhat TA, Kalathil SG, Leigh N, Muthumalage T, Rahman I, Goniewicz ML, Thanavala YM. Acute effects of heated tobacco product (IQOS) aerosol-inhalation on lung tissue damage and inflammatory changes in the lungs. Nicotine Tob. Res. 2021 Jun 8;23(7):1160-1167.
- Thanavala Y and Goniewicz ML. Vaping-induced severe respiratory disease outbreak: what went wrong? Lancet Resp Med 2019,7;12:1014-5.
- Kalathil S, Hutson A, Barbi J Iyer R, Thanavala Y. Augmentation of IFN-γ+ CD8+ T cell responses correlates with survival of HCC patients on sorafenib therapy. JCI Insight. 2019 Aug 8;4(15): e 130116.
- Kalathil S, Lugade A, Miller A, Iyer R, Thanavala Y. PD-1+ and Foxp3+ T cell reduction correlates with survival of HCC patients after sorafenib therapy. JCI Insight. 2016 Jul 21;1(11): e86182.
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Department of Immunology
Roswell Park Comprehensive Cancer Center
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Buffalo, NY 14263