Specializing In:
- Laboratory Animal Medicine
- Comparative Oncology
Research Interests:
- Comparative oncology models of viral hepatitis and hepatocellular carcinoma
- VX2 transplantable carcinoma model of head and neck cancer
- Preclinical pharmacokinetic and toxicology testing in comparative oncology models
Biography
I joined Roswell Park Comprehensive Cancer Center in July 2009 as the Clinical Veterinarian in the Comparative Oncology Shared Resource. I earned my DVM degree from Cornell University College of Veterinary Medicine in 1997 and completed residency training in Laboratory Animal Medicine at the State University of New York at Buffalo in 2008.
As part of the Comparative Oncology Shared Resource (COSR), I am committed to providing high quality veterinary care for the animals housed in the resource and in providing animal use training to researchers. Additionally, my research interests include the woodchuck hepatitis virus infected woodchuck as a model of viral hepatitis and hepatocellular carcinoma, the VX2 carcinoma transplantable rabbit tumor model, and pre-clinical pharmacokinetic and toxicology testing in various species.
Positions
Roswell Park Comprehensive Cancer Center
- Assistant Professor of Oncology
- Clinical Veterinarian, COSR
Background
Education and Training
- 1997 - DVM, Cornell University College of Veterinary Medicine, Ithaca, NY
Residency
- 2005-2008 - Laboratory Animal Medicine, State University of New York at Buffalo, Buffalo, NY
Board Certification
- American College of Laboratory Animal Medicine
Professional Memberships
- American College of Laboratory Animal Medicine (ACLAM)
- American Veterinary Medical Association (AVMA)
- American Association of Laboratory Animal Science (AALAS)
- Buffalo Academy of Veterinary Medicine (BAVM)
Professional Experience
- 2009-present: Clinical Veterinarian, Comparative Oncology Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY
- 2006-2009: Clinical Veterinarian, Comparative Medicine – Laboratory Animal Facility, State University of New York at Buffalo, Buffalo, NY
Honors & Awards
- 2009 - Henry and Lois Foster Award - Highest score on the American College of Laboratory Animal Medicine board exam
Publications
• Bellezza CA, Sexton S, Curtin L, Concannon PW, Baldwin BH, Graham L, Hornbuckle WE, Roth L, Tennant BC. The laboratory woodchuck (Marmota monax). In Laboratory Animal Medicine, 3rd ed.; Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, Fox JG, editor. Amsterdam: Elsevier, 2015; 351-386.
• Kim M, Powers CA, Curtin LI, Fisher DT, Sexton S, Gurova KV, Skitzki JJ, Iyer RV. A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks. J Surg Res. 2020 Jul;251:126-136. doi: 10.1016/j.jss.2020.02.002. Epub 2020 Mar 3. PubMed PMID: 32143057; PubMed Central PMCID: PMC7830851.
• Rich LJ, Sexton S, Curtin L, Seshadri M. Spatiotemporal Optoacoustic Mapping of Tumor Hemodynamics in a Clinically Relevant Orthotopic Rabbit Model of Head and Neck Cancer. Transl Oncol. 2017 Oct;10(5):839-845. doi: 10.1016/j.tranon.2017.08.004. Epub 2017 Sep 1. PubMed PMID: 28866260; PubMed Central PMCID: PMC5582377.
• Oakley E, Bellnier D, Hutson A, Cooper H, Habitzruther M, Sexton S, Curtin L, Tworek L, Mallory M, Henderson B, Shafirstein G. Irradiance, Photofrin(®) Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models. Photochem Photobiol. 2020 Mar;96(2):397-404. doi: 10.1111/php.13207. Epub 2020 Feb 18. PubMed PMID: 31887227; PubMed Central PMCID: PMC7138700.
• Curtin LI, Grakowsky JA, Suarez M, Thompson AC, DiPirro JM, Martin LB, Kristal MB. Evaluation of Buprenorphine in a Postoperative Pain Model in Rats. Comp Med. 2009 Feb;59(1):60-71. PubMed PMID: 19295055; PubMed Central PMCID: PMC2703135.