Emily Mackey, PhD, DVM, DACVP

Specialty: Anatomic Pathology
Veterinary Pathologist
COSR

Specializing In:

  • Comparative pathology
  • Preclinical studies
  • Spontaneous and infectious disease of preclinical models
  • Phenotyping of genetically engineered specimen

Research Interests:

  • Analog models of human disease
  • Pathology of immunocompromised and humanized preclinical trial models
  • Assessment of treatment efficacy and safety in human analog models of cancer
  • Immunopathology
  • Sex differences

Biography

I am an ACVP board-certified veterinary pathologist specializing in comparative pathology and the use of preclinical models in translational studies of human disease. My educational background has provided me with a strong foundation in veterinary pathology and biomedical research. I completed a DVM-PhD dual degree program at North Carolina State University College of Veterinary Medicine in 2021. As a graduate student, I led research projects investigating the mechanisms underlying mast cell-mediated diseases, particularly the influence of biological sex on mast cell phenotype and associated pathophysiological responses. Subsequently, I completed a residency in veterinary anatomic pathology at Wake Forest University School of Medicine, where I concentrated on comparative and laboratory animal pathology. I achieved board certification as a Diplomate of the American College of Veterinary Pathologists in 2024.

As a member of the Comparative Oncology Shared Resource (COSR), I am dedicated to advancing biomedical research through collaborative efforts by providing comparative pathology expertise to fellow investigators. I have extensive experience in preclinical research and pathological evaluation of laboratory animal species. I offer support in experimental design, animal modeling, and optimal sample collection strategies. Additionally, I specialize in research-specific pathology such as semi-quantitative tissue scoring, immunohistochemical quantification, phenotyping genetically-engineered preclinical models and assessing treatment efficacy and safety in preclinical models of cancer. I am eager to apply my expertise to further the efforts in comparative oncology and translational research at Roswell Park.

Positions

Roswell Park Comprehensive Cancer Center

  • Assistant Professor of Oncology
  • Veterinary Pathologist
  • COSR

Background

Education and Training

  • 2019 – PhD - Comparative Biomedical Sciences, North Carolina State University, Raleigh, NC
  • 2021 - Doctor of Veterinary Medicine – North Carolina State University College of Veterinary Medicine, Raleigh, NC

Residency

  • 2021-2024 - Veterinary Anatomic Pathology, Wake Forest School of Medicine, Winston-Salem, NC

Board Certification

  • Diplomate - American College of Veterinary Pathologists (Anatomic)

Professional Memberships

  • American College of Veterinary Pathologists
  • Society for Toxicologic Pathology
  • Davis-Thompson Foundation
  • American Veterinary Medical Association
  • Buffalo Academy of Veterinary Medicine

Honors & Awards

  • 2024 - Atrium Health Wake Forest Baptist Culture Commitment Award, “We create a space where all belong”, 2024
  • 2023 - Davis-Thompson Foundation Pathology Trainee and Scholarship Award, American College of Veterinary Pathologists Annual Meeting
  • 2020 - Phi Zeta Honor Society of Veterinary Medicine Inductee, NC State University College of Veterinary Medicine
  • 2019 - 1st Place Young Investigator Award, Society of Toxicologic Pathology 38th Annual Symposium

Publications

  Full Publications list on PubMed

Quist E, Choudhary S, Lejeune T, Mackey E, Thakur P, Hobbie K, Duggan A. Proceedings of the 2024 Division of Translational Toxicology Satellite Symposium. Toxicology Pathology (2024)

Mackey E, and Adam J. Moeser. Sex Differences in Mast Cell–Associated Disorders: A Life Span Perspective. Cold Spring Harbor Perspectives in Biology 14.10 (2022): a039172. PMID: 35817512

Mackey E, Brittany L. Rasche, Peter J. Early, Natalia Zidan, and Tatiane Terumi Negrão Watanabe. Pathology in Practice. Journal of the American Veterinary Medical Association 259, no. S2 (2022): 1-5. PMID: 35560130

Mackey EM, Bali V, Fardisi M, Thelen K, Trowbridge M, Jordan C, & Moeser AJ. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood. Accepted for publication in Proceedings of the National Academy of Sciences of the United States of America. (2020) PMID: 32917815

Mackey E, Ayyadurai S, Pohl CS, D’Costa S, Li Y, Moeser AJ. (2016). Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress. Biology of Sex Differences, PMID: 27895892