David Restle, MD

Specialty: Surgical Oncology
Department of Surgical Oncology

Research Interests:

  • Translational research
  • Tumor immunology

Biography

I am a Fellow in Complex General Surgical Oncology at Roswell Park Comprehensive Cancer Center. I received my undergraduate degree in Bioengineering from the University of Pennsylvania. I completed medical school and residency in General Surgery at Stony Brook University. During residency, I completed a three-year research fellowship at Memorial Sloan Kettering Cancer Center, where I conducted research in tumor immunology and CAR T-cell therapy. 

My clinical and academic interests include gastrointestinal and hepatobiliary surgery, peritoneal surface malignancies, and tumor immunology.

Positions

Roswell Park Comprehensive Cancer Center

  • Surgical Oncology Fellow
  • Department of Surgical Oncology

Background

Education and Training

  • 2018 - MD - Stony Brook University School of Medicine
  • 2009-2013 - Bachelor of Science in Engineering in Bioengineering, University of Pennsylvania

Residency

  • 2018-2020 - General Surgery, Stony Brook University School of Medicine

Fellowship

  • 2020-2023 - Research Fellowship, Memorial Sloan Kettering Cancer Center

Professional Memberships

  • Society of American Gastrointestinal and Endoscopic Surgeons

Honors & Awards

  • 2019 - Intern of the Year Award, Stony Brook General Surgery
  • 2018 - Scholarly Concentration in Research, Stony Brook Medicine
  • 2013 - Magna Cum Laude, University of Pennsylvania

Publications

  Full Publications list on PubMed
  • Restle D, Amador-Molina A, Misawa K, Banerjee S, Ku G, Adusumilli PS. Intraperitoneal CAR T-cell therapy for peritoneal carcinomatosis from gastroesophageal cancer: preclinical investigations to a phase I clinical trial (NCT06623396). J Immunother Cancer. 2025
  • Restle D, Dux J, Li X, Byun AJ, Choe JK, Li Y, Vaghjiani RG, Thomas C, Misawa K, Tan KS, Jones DR, Chintala NK, Adusumilli PS. Organ-specific heterogeneity in tumor-infiltrating immune cells and cancer antigen expression in primary and autologous metastatic lung adenocarcinoma. J Immunother Cancer. 2023.
  • Byun AJ, Grosser RA, Choe JK, Rizk NP, Tang LH, Molena D, Tan KS, Restle D, Cheema W, Zhu A, Gerdes H, Markowitz AJ, Bains MS, Rusch VW, Jones DR, Adusumilli PS. A Prospective Clinical Trial to Evaluate Mesothelin as a Biomarker for the Clinical Management of Patients With Esophageal Adenocarcinoma. Ann Surg. 2023.
  • Saxena V, Kim M, Keah NM, Neuwirth AL, Stoeckl BD, Bickard K, Restle DJ, Salowe R, Wang MY, Steinberg DR, Mauck RL. Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement. Tissue Engineering Part A. 2016.
  • Restle DJ, Zhang D, Hung G, Howard J, Kallel F, Acker MA, Atluri P, Bartoli CR. Preclinical Models for Translational Investigations of Left Ventricular Assist Device-associated von Willebrand Factor Degradation. Artificial Organs. 2015.