Metastasis, or the spread of cancer cells from a primary tumor to distant organs, lacks effective treatment options and remains a major cause of cancer-related deaths. To better understand how metastasis works — and how it might be controlled — scientists at Roswell Park Comprehensive Cancer Center have zeroed in on the role of the metabolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) in the spread of triple-negative breast cancer (TNBC). Their study, “Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence,” appears today in Cell Reports.