Up to 30% of patients newly diagnosed with acute myeloid leukemia (AML) have an FLT3 gene mutation, which is associated with a high risk of relapse and a very poor prognosis. But clinical studies have shown that drugs called FLT3 inhibitors can extend long-term survival in these patients, especially when given in combination with other treatments. A phase 2 clinical trial led by Roswell Park Comprehensive Cancer Center tested that strategy for treating FLT3-mutated AML, and the encouraging results are newly reported in Journal of Clinical Oncology, a journal of the American Society of Clinical Oncology.