What Is Metastatic Breast Cancer?

Cancer that has spread to a distant organ is called metastatic disease. With breast cancer, the most common sites for metastases are the lungs, liver and bone. We treat metastatic disease with a multidisciplinary team approach, calling on the best experts in breast cancer care. New advances in treating metastatic disease are made everyday, and may offer many years of high-quality life. We offer several options for treating metastatic breast cancer and improving quality of life including:

• Clinical trials of the latest drugs and approaches such as a breast cancer vaccine and other immunotherapies.
• Gamma Knife radiosurgery to treat metastases to the brain
• Chemotherapy
• Bone-strengthening treatments using agents such as zoledronic acid (Zometa)
• Endocrine or anti-estrogen therapy
• Radiation therapy to distant sites
• Supportive & palliative care to address ongoing symptoms and quality of life
• Rehabilitation medicine, including physical and occupational therapy

Clinical trials for metastatic breast cancer

Clinical trials are scientific studies that assess how well new treatments (that have already been studied in the laboratory) work in real-life situations. Clinical trials are the way cancer researchers examine how effective a new agent, a new combination of drugs, or new therapy is in a particular patient group, whether it works better than current standard treatments, or causes fewer, less toxic side effects.

The need for new treatments for metastatic breast cancer remains urgent. Current therapies may extend survival in some patients, but eventually, they stop working and the cancer progresses.

Roswell Park’s robust research program includes many ongoing trials for patients with metastatic breast cancer. More than a dozen trials are open and enrolling participants. These trials involve various methods and approaches, including:

• Novel chemotherapy agents, such as new anti-cancer drugs that interrupt the growth of rapidly-dividing cancer cells, including some that may be taken orally, rather than through an IV infusion.
• Novel targeted agents, are potential new drugs designed to home in on the cancer cells (leaving other body cells alone) by targeting specific mutations within cancer cells, or by finding and attaching to specific proteins or receptors found only in the cancer cells.
• Immunotherapies, which aim to stimulate the body’s immune cells (such as T-cells) to recognize cancer cells as invaders and attack them. Immunotherapies have been less effective against breast cancer in part because the T-cells cannot get into the breast cancer cells. Roswell Park has clinical trials of several approaches to overcome this problem. These include a treatment vaccine, new immunotherapy drugs, new combinations of drugs, injecting immunotherapy drugs directly into the tumor and cellular therapies that re-engineer the T-cells to improve their effectiveness.