John Kane III, MD, FACS
Areas of Expertise:
Soft tissue sarcomas (all sites: extremity, truncal, intra-abdominal / retro peritoneal, head & neck, gastrointestinal stromal tumors (GIST))
Rare soft tissue and skin tumors
Merkel cell carcinoma
Carcinomatosis, primary peritoneal mesothelioma
Isolated regional therapy (Isolated limb perfusion (ILP) and isolated limb infusion (ILI)
I am an Associate Professor of Surgery and Chief of the Melanoma/Sarcoma service at Roswell Park Cancer Institute (RPCI). My interest in melanoma, sarcoma, and regional therapies dates back to the beginning of my practice over 12 years ago. I am the main sarcoma surgeon at RPCI and treat soft tissue sarcomas at all anatomic locations; extremity, truncal, intra-abdominal/retroperitoneal, head and neck, and gastrointestinal stromal tumors (GIST). I am a member of major sarcoma groups including the NCCN Sarcoma Panel, the Connective Tissue Oncology Society, and the Radiation Therapy Oncology Group (RTOG) Sarcoma Committee. I have been the lead investigator for several sarcoma trials at RPCI, have authored multiple papers on the treatment of soft tissue sarcomas, and have been an invited speaker on this topic at national meetings. I oversee our weekly sarcoma/soft tissue tumor multidisciplinary conference where all new sarcoma and rare soft tissue tumor cases are discussed in order to develop the optimal treatment plan.
I also treat unusual benign and locally aggressive soft tissue tumors. These include desmoid/aggressive fibromatosis, dermatofibrosarcoma protuberans (DFSP), neurogenic tumors such as neurofibroma and schwannoma, large and atypical intramuscular lipomatous tumors, solitary fibrous tumor, ganglioneuroma, and adrenal myelolipoma. As noted above, our weekly multidisciplinary conference allows for a thorough discussion of the patients with these various tumors. In some cases, surgery may not even be necessary.
I have a significant clinical interest in melanoma and other aggressive cutaneous malignancies such as Merkel cell carcinoma. Our Institution has been offering sentinel lymph node biopsy since 1996 and I have personally performed over 450. For patients with nodal metastatic disease, I frequently perform axillary dissections (very different from what is done for breast cancer), superficial and deep groin dissections, and even less common lymphadenectomies in the epitrochlear and popliteal basins. I have advanced the regional therapies program at RPCI for patients with isolated extremity disease (in transit melanoma, Merkel cell carcinoma, and some sarcomas) that is no longer amenable to simple surgical excision. Isolated limb perfusion (ILP) or isolated limb infusion (ILI) can still be potentially curative in these situations. Roswell Park Cancer Institute is one of only two institutions in New York State that performs these isolated regional therapies.
As another type of isolated regional therapy, I developed the cytoreduction/hyperthermic intraperitoneal chemoperfusion (HIPEC) program at RPCI in 2002. I routinely perform cytoreductive surgery/HIPEC for appendiceal neoplasms, colorectal cancer, mesothelioma, and other peritoneal surface malignancies. In addition to patients with these diseases in WNY, I have provided this treatment option for the province of Ontario.
Aside from my clinical responsibilities, I serve as the Surgical Oncology Fellowship Program Director and on the Executive Council of the Society of Surgical Oncology. I am a fellow of the American College of Surgeons and a member of multiple surgical and oncologic societies, including the Society of Surgical Oncology, the American Society of Clinical Oncology, and the Association for Academic Surgeons. I have served as the past president for both the WNY Chapter of the American College of Surgeons and the Buffalo Surgical Society. I was also previously the WNY State Chair for the ACS Commission on Cancer.
Development of a novel fully recombinant heat shock protein-gp100 melanoma vaccine for a phase I clinical trial
Correlation of soft tissue sarcoma tissue microarray biomarker expression with patient outcome
Use of pre-clinical models to examine novel/combination therapies for isolated regional therapy and soft tissue sarcomas
Education and Training:
MD - Johns Hopkins University School of Medicine, Baltimore, MD (1987 – 1991)
University of Pittsburgh, Department Surgery, Pittsburgh, PA (1991 – 1998)
Surgery, American Board of Surgery
Research Fellowship, University of Pittsburgh, Department Surgery, Pittsburgh, PA (1994 – 1996)
Surgical Fellowship, Roswell Park Cancer Institute, Department of Surgical Oncology, Buffalo, NY (1998 – 2000)
- Wide excision or Mohs micrographic surgery for the treatment of primary dermatofibrosarcoma protuberans. American journal of clinical oncology 2010; 33(3):300-303 .
- Recurrent giant cell fibroblastoma treated with Mohs micrographic surgery. Dermatologic surgery 2010; 36(3):417-421 .
- Superior antitumor response induced by large stress protein chaperoned protein antigen compared with peptide antigen. Journal of immunology (Baltimore, Md. : 1950) 2010; 184(11):6309-6319 .
- Soft tissue sarcoma. Journal of the National Comprehensive Cancer Network : JNCCN 2010; 8(6):630-674 .
- Testicular/scrotal soft tissue sarcomas: Confusing presentation and diverse biologic behavior. Annals of surgical oncology 2010; 17(Suppl. 1):S33 .
- Peritoneal lavage with distilled water is tumoricidal: Science or legend?. Annals of surgical oncology 2010; 17(Suppl. 1):S24-S25 .
- The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma. Cancer 2009; 115(24):5836-5844 .
- A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. Journal of the American College of Surgeons 2009; 208(5):706-715; discussion 715-7 .
- Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. Journal of surgical oncology 2009; 99(1):42-47 .
- Nevus spilus with synchronous melanomas: case report and literature review. Journal of cutaneous medicine and surgery 2009; 13(2):96-101 .
- Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis. Annals of surgical oncology 2009; 16(9):2570-2578 .
- Factors associated with actual long-term survival following soft tissue sarcoma pulmonary metastasectomy. European journal of surgical oncology 2009; 35(4):356-361 .
- In-transit merkel cell carcinoma treated with isolated limb perfusion or isolated limb infusion: a case series of 12 patients. Dermatologic surgery 2011; 37(3):357-364 .
- Thick primary melanoma has a heterogeneous tumor biology: an institutional series. World journal of surgical oncology 2011; 9:40 .
- Repair of large abdominal defects with prostheses following Mohs micrographic surgery: case series and review of literature. Dermatologic surgery 2008; 34(3):403-406 .
- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Annals of surgical oncology 2007; 14(1):128-133 .
- Surgical management of metastatic peritoneal or pleural disease. Seminars in oncology 2007; 34(3):215-225 .
- Water: a simple solution for tumor spillage. Annals of surgical oncology 2011; 18(8):2357-2363 .
- Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Archives of surgery (Chicago, Ill. : 1960) 2011; 146(7):870-875 .
- Duodenal gastrointestinal stromal tumors: A diagnostic and surgical challenge. Annals of surgical oncology 2008; 15(Suppl. 2):87 .
- Phase II trial of Neoadjuvant/Adjuvant imatinib mesylate (IM) for advanced primary and recurrent operable GI stromal tumor (GIST) - early results of RTOG 0132. Annals of surgical oncology 2008; 15(Suppl. 2):26 .
- Thick primary melanomas: A heterogeneous tumor biology? . Annals of surgical oncology 2008; 15(Suppl. 2):98 .
- Dermatofibrosarcoma protuberans: Surgical modality, margin status, and outcome. Annals of surgical oncology 2007; 14(2 Suppl.):117-118 .
- Characterization of PDGF alpha/beta and PDGFR alpha/beta expression in dermatofibrosarcoma protuberans: Implications for targeted molecular therapy. Annals of surgical oncology 2008; 15(Suppl. 2):100-101 .
- Merkel cell carcinoma: The role of sentinel lymph node biopsy and adjuvant radiation. Annals of surgical oncology 2008; 15(Suppl. 2):99 .
- Systemic thermal therapy alters the non-permissive tumor microenvironment during adoptive immunotherapy. Annals of surgical oncology 2008; 15(Suppl. 2):96 .
- Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): Long-term follow-up results of RTOG 0132 : ASCO Meeting Abstracts Part 1. Journal of clinical oncology 2011; 29(15 Suppl.):10057 .
- CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma. Journal of immunology (Baltimore, Md. : 1950) 2011; 187(6):2905-2914 .
- RTOG Phase II Trial of Preoperative Image Guided Radiotherapy (IG-RT) For Primary Soft Tissue Sarcoma of the Extremity: Acute Toxicity Report. International journal of radiation oncology, biology, physics 2011; 81(2 Suppl.):S117 .
- Preface. Surgical oncology clinics of North America 2012; 21(2):xv-xvi .
- Margin status, local recurrence, and survival: correlation or causation?. Surgical oncology clinics of North America 2012; 21(2):255-267 .
- Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330. Sarcoma 2012; 2012 :659485 .
- Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132. Annals of surgical oncology 2012; 19(4):1074-1080 .
- The morbidity of cytoreduction/hyperthermic intraperitoneal chemoperfusion (HIPEC) in the modern era. Journal of clinical oncology 2012; 30(15 Suppl.):Abstract #e14172 .
- Systemic therapy in advanced cutaneous squamous cell carcinoma (CSCC): The Roswell Park experience : ASCO Meeting Abstracts Part 1. Journal of clinical oncology 2012; 30(15 Suppl.):Abstract #e19041 .