James Thompson, MD

PrintE-mail
Assistant Professor, Department of Medicine
Assistant Member, Department of Immunology
Roswell Park Cancer Institute

Profile

Areas of Expertise: 
Acute lymphoblastic leukemia (ALL)
Acute myeloid leukemia (AML)
Chronic myeloid leukemia (CML)
Hematologic Oncology
Myelodysplastic syndrome (MDS)
Myeloproliferative diseases (MPD)

Research

Research Interests: 
Etiology of MDS and unexplained anemia (UA) of aging
Role of mitochondrial DNA (mtDNA) mutations in immunosenescence
Role of mtDNA mutations in the development of MDS and UA

Background Information

Education and Training: 
MD - Columbia University College of Physicians & Surgeons, New York, NY
Residency: 
University of Pennsylvania, Philadelphia, PA
Board Certification: 
Hematology, American Board of Internal Medicine
Medical Oncology, American Board of Internal Medicine
Internal Medicine, American Board of Internal Medicine
Fellowships: 
University of Pennsylvania, Philadelphia, PA

Publications

Publications: 
  • Wetzler M, Wang E, Thompson J, Baer M, Block AM, Sait S, Barcos M, Tighe S, Ford LA, Andrews C, Baumann H. Priming with arsenic trioxide improves the outcome of newly diagnosed acute myeloid leukemia patients < 60 years old treated with high-dose cytarabine and idarubicin. Haematologica 2010; 95(Suppl. 2):Abstract #64
  • Kinder M, Thompson JE, Wei C, Shelat SG, Blair IA, Carroll M, Pure E. Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling. Experimental hematology 2010; 38(11):1036-1046.e1-4
  • Lee HJ, Trump D, Johnson CS, Wang ES, Thompson JE, Griffiths EA, Vigil CE, Barcos M, Block A, Sait S, Ford LA, Wilding G, Wei T, Muindi J, Wetzler M. Subnormal vitamin D levels are associated with adverse outcome in newly-diagnosed similarly-treated adult acute myeloid leukemia (AML) patients. Blood 2010; 116(21):Abstract #1041
  • Block AW, Thompson JE, Wang ES, Starostik P, Deeb G, Sait SN, Ford L, Wilding GE, Groman AE, Wetzler M. The role of FLT3 in sole trisomy 8 acute myeloid leukemia. Journal of clinical oncology 2010; 28(15 Suppl.):6562
  • Chen ML, Carroll M, Kundu M, Selak MA, Prolla TA, Kujoth GC, Tan W, Wilding GE, Yu X, Shelat SG, Hochberg ML, Logan TD, Thompson JE. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood 2009; 114(19):4045-4053
  • Greenberg PL, Maness LJ, Millenson M, Nimer SD, O'Donnell MR, Schroeder MA, Shami PJ, Stone RM, Thompson JE, Komrokji R, Head D, Gore SD, Attar E, Bennett JM, Bloomfield CD, De Castro CM, Deeg HJ, Foran JM, Gaensler K, Garcia-Manero G, Westervelt P. Myelodysplastic syndromes. Journal of the National Comprehensive Cancer Network : JNCCN 2011; 9(1):30-56
  • Safdar A, Prolla TA, Kujoth GC, Mocellin NJ, Melov S, Thompson JE, Akhtar M, Hettinga BP, Little JP, Ogborn DI, Bourgeois JM, Tarnopolsky MA. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proceedings of the National Academy of Sciences of the United States of America 2011; 108(10):4135-4140
  • Lee HJ, Thompson JE, Wang ES, Wetzler M. Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives. Cancer 2011; 117(8):1583-1594
  • Noor SJ, Wang ES, Thompson JE, Block AW, Sait SN, Barcos M, Ford LA, Wilding GE, Tan W, Wetzler M. Myeloid blastic transformation of myeloproliferative neoplasms--a review of 112 cases. Leukemia research 2011; 35(5):608-613
  • Erdogan B, Carroll M, Thompson JE, Baldwin DA, Tobias J, Isett RB, Rinker E, Tedesco J, Qualtieri J, Facey C, Kim AS. Diagnostic microRNAs in myelodysplastic syndrome. Experimental hematology 2011; 39(9):915-926.e2
  • Facey C, Isett RB, Tobias J, Baldwin DA, Thompson JE, Carroll M, Kim AS. MicroRNA Diagnostic Signature of Myelodysplastic Syndrome. Blood 2009; 114(22):700-701
  • Noor S, Tan W, Wilding G, Ford LA, Barcos M, Sait SNJ, Block AW, Thompson JE, Wang ES, Wetzler M. Myeloid Blastic Transformation of Myeloproliferative Neoplasms - A Review of 113 Cases. Blood 2009; 114(22):1210
  • Varadarajan R, Licht A, Hyland AJ, Ford LA, Barcos M, Sait SNJ, Block AW, Baer MR, Thompson JE, Wang ES, Wetzler M. Smoking Adversely Affects Survival in Acute Myeloid Leukemia Patients. Blood 2009; 114(22):407
  • Lee HJ, Wright KM, Kandeel E, Tan W, Wilding GE, Ford LA, Sait SN, Block AMW, Barcos MP, McCarthy PL, Vigil CE, Griffiths EA, Thompson JE, Wang ES, Wallace PK, Wetzler M. The role of minimal residual disease (MRD) by flow cytometry (FC) in predicting outcome in similarly treated acute lymphoblastic leukemia (ALL) patients : ASCO Meeting Abstracts Part 1. Journal of clinical oncology 2011; 29(15 Suppl.):6592
  • Vigil CE, Griffiths EA, Thompson JE, Tan W, Greene J, Ford LA, Wang ES, Wetzler M. A phase II study of clofarabine and daunorubicin in patients age 60 or older with newly diagnosed adult acute myeloid leukemia. Journal of clinical oncology 2012; 30(15 Suppl.):Abstract #6602
  • Sardesai SD, Tan W, Ford LA, Deeb G, Block AMW, Sait SNJ, McCarthy PL, Vigil CE, Griffiths EA, Thompson JE, Wang ES, Wallace PK, Wetzler M. Predicting outcome based on minimal residual disease (MRD) using multiparameter flow cytometry (FC) in acute myeloid leukemia (AML) patients (Pts) : ASCO Meeting Abstracts Part 1. Journal of clinical oncology 2012; 30(15 Suppl.):Abstract #6565