Dr. Yuesheng Zhang joined the faculty of Roswell Park Cancer Institute in 2003 and has been a Professor of Oncology since 2007. He has also been a Senior Member of the Roswell Park Graduate Division, the State University of New York Graduate College since 2003. He came to RPCI from the University of Arizona, Arizona Cancer Center, where he served as an Assistant Professor of Medicine.
Dr. Zhang earned his MD in 1984 and MS in 1988 from Zhejiang University School of Medicine (formerly Zhejiang Medical University, Hangzhou, China), and his PhD in Pharmacology and Molecular Sciences in 1996 from the Johns Hopkins University School of Medicine (Baltimore, USA), where he also completed postdoctoral fellowship and served as a junior faculty member.
Dr. Zhang is a member of the American Association for Cancer Research (AACR) and the American Society of Biochemistry & Molecular Biology (ASBMB). Dr. Zhang is also a member of the editorial boards of Molecular Cancer Therapeutics, Molecular Nutrition and Food Research, and Journal of Carcinogenesis and Mutagenesis. He has served on many NIH study sections, and has been an Honorary Professor in the Second Affiliated Hospital of Hebei Medical University (Shijiazhuang, China) since 2006.
Dr. Zhang has had a long standing interest in naturally occurring isothiocyanates as cancer chemopreventive agents and bladder cancer chemoprevention. More recently, Dr. Zhang has also been studying the molecular basis of gender disparity of bladder cancer risk. Bladder cancer risk is 3-4 times higher in men than in women. His group also recently discovered that human prolidase is an inhibitory ligand of ErbB1 and ErbB2, both of which are cell surface receptor tyrosine kinases and play important roles in various cancers. Studies to further understand the interaction of prolidase with ErbB1 and ErbB2 and to assess the antitumor activity of prolidase are ongoing.
Dr. Zhang has authored or co-authored over 120 journal articles, book chapters and meeting abstracts. As of July 2015, his papers have been cited over 9,650 times.
Zhang Y. Allyl isothiocyanate as a cancer chemopreventive phytochemical. Molecular Nutrition & Food Research 2010; 54: 127-135.
Randall KL, Argoti D, Paonessa JD, Ding Y, Oaks Z, Zhang Y, Vouros P. An improved liquid chromatography-tandem mass spectrometry method for the quantification of 4-aminobiphenyl DNA adducts in urinary bladder cells and tissues. Journal of Chromatography A 2010; 1217: 4135-4143.
Bhattacharya A, Tang L, Li Y, Geng F, Paonessa JD, Chen SC, Wong MKK, Zhang Y. Inhibition of bladder cancer development by allyl isothiocyanate. Carcinogenesis 2010; 31: 281-286.
Tang L, Zirpoli GR, Guru K, Moysich KB, Zhang Y, Ambrosone CB, McCann SE. Intake of cruciferous vegetables modifies bladder cancer survival. Cancer Epidemiology, Biomarkers & Prevention 2010; 19: 1806-1811.
Tang L, Zirpoli GR, Jayaprakash V, Reid ME, McCann SE, Nwogu, CE, Zhang Y, Ambrosone CB, Moysich KB. Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study. BMC Cancer 2010; 10: 162-171.
Munday R, Zhang Y, Paonessa JD, Munday CM, Wilkins AL, Babu J. Synthesis, biological evaluation and structure-activity relationships of dithiolethiones as inducers of cytoprotective Phase 2 enzymes. Journal of Medicinal Chemistry 2010; 53: 4761-4767.
Ding Y, Paonessa JD, Randall KL, Argoti D, Chen L, Vouros P, Zhang Y. Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues. Carcinogenesis 2010; 31: 1999-2003.
Bhattacharya A, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y. Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion. Carcinogenesis 2010; 31: 2105-2110.
Paonessa JD, Ding Y, Randall KL, Munday R, Argoti D, Vouros P, Zhang Y. Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention. Cancer Research 2011; 71: 3904-3911.
Geng F, Tang L, Li Y, Yang L, Choi KS, Kazim AL, Zhang Y. Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 phosphorylation. Journal of Biological Chemistry 2011; 286: 32259-32267.
Zhang Y. The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates. Carcinogenesis 2012; 33: 2-9.
Zhang Y. The 1,2-benzenedithiole-based cyclocondensation assay, a valuable tool for measurement of chemopreventive isothiocyanates. Critical Reviews in Food Science and Nutrition 2012; 52: 525-532.
Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y. The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer. Carcinogenesis 2012; 33: 394-398.
Li Y, Paonessa JD, Zhang Y. Mechanism of chemical activation of Nrf2. PLoS ONE 2012; 7: e35122.
Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y. Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention. British Journal of Nutrition 2013; 109: 25-32.
Yang L, Li Y, Ding Y, Choi KS, Kazim AL, Zhang Y. Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling. Journal of Biological Chemistry 2013; 288: 2365-2375.
Guo Y, Zhang Y, Wen D, Duan W, An T, Shi P, Wang J, Li Z, Chen X, Li C. The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model. Laboratory Investigation 2013; 93: 825-833.
Zhang Y. Understanding the gender disparity in bladder cancer risk: The impact of sex hormones and liver on bladder susceptibility to carcinogens. Journal of Environmental Science and Health, Part C 2013; 31: 287-304.
Bhattacharya A, Li Y, Shi Y, Zhang Y. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination. Carcinogenesis 2013; 34: 2593-2599.
Tang L, Paonessa JD, Zhang Y, Ambrosone CB, McCann SE. Total isothiocyanate yield from raw cruciferous vegetables commonly consumed in the United States. Journal of Functional Foods 2013; 5: 1996-2001.
Zucker S, Fink E, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner P, Wawrzyniak JA, Foley C, Leonova KI, Grimm M, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin A, Zhang Y, Kaminski N, Segal B, Nikiforov M. Nrf2 amplifies oxidative stress via induction of Klf9. Molecular Cell 2014; 53: 916-928.
Yang L, Li Y, Zhang Y. Identification of prolidase as a high affinity ligand of the ErbB2 receptor and its regulation of ErbB2 signaling and cell growth. Cell Death & Disease 2014; 5: e1211.
Bhattacharya A, Klaene JJ. Li Y, Paonessa JD, Stablewski AB, Vouros P, Zhang Y. The inverse relationship between bladder and liver in 4-aminobiphenyl-induced DNA damage. Oncotarget 2015; 6, 836-845.
Veeranki OL, Bhattacharya A, Tang L, Marshall JR, Zhang Y. Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer. Current Pharmacology Reports 2015; 1: 272-282.
Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing tumors by recombinant human prolidase and its enzymatically inactive mutant. EBioMedicine 2015; 2: 396-405.