Beyond its traditional functions in calcium homeostasis, vitamin D is involved in the development and progression of a number of diseases and conditions including cancer. Dr. Ma’s main research focus is on understanding the mechanisms of the anti-tumor effects of 1,25D3, the active metabolite of vitamin D, and its analogues, and the development of therapeutic strategies for the utilization of 1,25D3 in cancer care.
Her research interests include 1,25D3 regulation of apoptosis, migration and invasion in cancer. Her current research focuses on the regulation of miRNAs and their target genes involved in bladder cancer cell migration and invasion by 1,25D3, and the potential underlying mechanisms. She is also interested in applying 1,25D3 in the combinational treatment with chemotherapeutic agents to potentiate their anti-tumor effects.
Past and current funding include: Roswell Park Alliance Foundation.