Dr. Thomas J. Dougherty joined the staff of Roswell Park Cancer Institute (RPCI) in 1970, as a Research Associate in the Department of Experimental Biology. The following year, he was appointed Cancer Research Scientist and Head of Radiation Biology, Department of Radiation Medicine, and was appointed Chief, Photodynamic Therapy (PDT) Center, 1988. He also is a Research Professor, Molecular & Cellular Biophysics, Roswell Park Graduate Division, University at Buffalo (UB), Research Professor of Radiation Oncology, UB School of Medicine & Biomedical Sciences, and President & Research Director, The Oncologic Foundation of Buffalo. Dr. Dougherty earned his doctoral degree in Physical Organic Chemistry at Ohio State University, Columbus, in 1959.
Dr. Dougherty was awarded a lifetime achievement award from the American Society of Photodynamics.
Dr. Dougherty is a member of the American Association for Cancer Research, American Chemical Society, American Society for Laser Medicine & Surgery, American Society for Photobiology, European Society for Photobiology, International Photodynamic Association, and Radiation Research Society. Dr Dougherty has authored or co-authored more than 200 journal publications, book chapters and abstracts, and holds 25 patents. He is Assistant Editor of International Photodynamics and serves on the editorial boards of Lasers in Surgery and Medicine and the Journal of Clinical Laser Medicine & Surgery. He is a reviewer for the British Journal of Cancer, Cancer Research, European Journal of Cancer, International Journal of Radiation Oncology, Journal of the National Cancer Institute, Journal of Surgical Oncology, New England Journal of Medicine, and Photochemistry and Photobiology. Dr. Dougherty also is a grant reviewer for the National Cancer Institute, American Cancer Society, and the Swiss National Science Foundation. Dr. Dougherty’s work has been the subject of several newspaper articles and television news programs, as well as a 30-minute special on CBS describing his trip to China in 1983 to lecture on photodynamic therapy.
Dr. Dougherty’s research interests focus on basic and clinical research in photodynamic therapy (PDT), which he developed at RPCI and is now approved by health agencies worldwide for the treatment of bladder, esophageal and lung cancers. Current research interests include clinical trials of a newly developed drug for PDT; quantitative studies to allow rational design of new photosensitizing drugs; Photofrin®-mediated PDT as an adjuvant to neurosurgery in an attempt to destroy tumor cells beyond the margin of surgical resection; parabolic quantitative structure-activity relationships and PDT; and purpurinimides as photosensitizers.
Dougherty TJ. Introduction. Methods in molecular biology (Clifton, N.J.) 2010;635:1-6
Bernstein ZP, Walder H, Adal A, Wallace P, Stewart C, Sumlin A, Kepner J, Mahajan SD, Schwartz SA, Gollnick S, Dougherty T, Poiesz B. Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and light. Current HIV research 2008; 6(2):152-163
Giuliano EA, MacDonald I, McCaw DL, Dougherty TJ, Klauss G, Ota J, Pearce JW, Johnson PJ. Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study. Veterinary ophthalmology2008; 11 Suppl. 1:27-34
Pandey SK, Dougherty TJ, Henderson BW, Oseroff AR, Bellnier DA, Shibata M, Liu TH, Missert JR, Morgan J, Zheng X, Pandey RK. Purpurinimide carbohydrate conjugates: effect of the position of the carbohydrate moiety in photosensitizing efficacy. Molecular pharmaceutics 2007; 4(3):448-464
Dougherty TJ, Gomer CJ. Introduction. Lasers in surgery and medicine 2011;43(7):541
Nava HR, Allamaneni SS, Dougherty TJ, Cooper MT, Tan W, Wilding G, Henderson BW. Photodynamic therapy (PDT) using HPPH for the treatment of precancerous lesions associated with barrett's esophagus. Lasers in surgery and medicine 2011; 43(7):705-712
Bernstein ZP, Dougherty T, Gollnick S, Schwartz S, Mahajan S, Kepner J, Sumlin A, Stewart C, Wallace P, Walder H, Poiesz B. Photopheresis in HIV-1 infected patients utilizing (Benzoporphyrin derivative Verteporfin/BPD-MA) and light. Blood 2007; 110(11 Part 1):Abstract #2275