Susan McCann

PhD, RD

Specializing In:

Nutritional epidemiology Dietary interventions Gut microbiome Analysis of complex dietary data

Special Interests:

Role of diet and the gut microbiome in cancer etiology and prognosis Role of phytochemicals in cancer etiology and prognosis Intervention approaches

About Me

Biography:

I am a registered dietitian and with training in nutrition, epidemiology, and methods of analyzing complex dietary and epidemiologic data. My research interests include the relationships between diet and cancer, especially cancers of the breast, endometrium, and ovary. More specifically, I am interested in phytochemicals as dietary compounds affecting cancer risk and prognosis, and am further interested in the effect of genetic variation on these relationships. I have conducted several dietary intervention studies to investigate the role of dietary components in cancer or cancer related risk factors. I have also been involved in research that utilizes data reduction analytic methods such as principal components analysis. Finally, I am interested in the application of metabolomics and genomics to problems of diet in the etiology and prognosis of cancer and the role of the gut microbiome in cancer etiology.

I have conducted several clinical trials funded by the National Center for Complementary and Alternative Medicine and National Cancer Institute (NIH) studying the effects of flaxseed on breast cancer etiology and survival. Among these is an investigation of the role of modification of dietary glycemic load in expression of miRNAs related to cancer and energy metabolism which reported that a low glycemic diet may affect expression of several miRNAs related to energy metabolism and cancer processes. I have recently completed a flaxseed intervention study in healthy African American and Caucasian postmenopausal women to investigate the interaction between the gut microbiome and genetic variation on changes in steroid hormone metabolism in response to the flaxseed intervention.

I have authored or co-authored more than 90 journal articles, abstracts, and book chapters, served as a First Editor of Nutrition Research Reviews, and as an ad hoc reviewer for the American Journal of Clinical Nutrition, American Journal of Epidemiology, Cancer Causes and Control, and Cancer Epidemiology, Biomarkers and Prevention, JNCI, JCO, and other peer-reviewed cancer journals.

I am actively involved in the education of scientists at Roswell Park Cancer Institute. I have mentored numerous graduate students in the Interdisciplinary Sciences Masters degree program, and several masters and doctoral candidates in Epidemiology (University at Buffalo) and Cancer Prevention (Roswell Park).


Credentials

Positions

Roswell Park Comprehensive Cancer Center
  • Member and Professor of Oncology
  • Cancer Prevention and Control
University at Buffalo
  • Research Professor
  • Department of Epidemiology and Environmental Health
  • Department of Exercise and Nutrition Sciences

Background

Education and Training:

  • PhD Epidemiology and Community Health, University at Buffalo, nutritional epidemiology, 1998
  • MS Nutrition, University of Mississippi, nutrition and sports medicine, 1983

Fellowship:

  • NCI Postdoctoral Fellowship, Department of Social and Preventive Medicine, University at Buffalo, 1998-2001
  • NCI Predoctoral Fellowship, Department of Social and Preventive Medicine, University at Buffalo, 1992-1995

Professional Memberships:

  • American Association for Cancer Research
  • Academy of Food and Nutrition
  • American Society for Nutrition

Honors & Awards

  • Academic Service Award, School of Public Health and Health Professions, University at Buffalo, 2006
  • Saxon Graham Award for Excellence in Epidemiology, Department of Social and Preventive Medicine, University at Buffalo, 1998

Research

Research Overview:

Dr. McCann is a registered dietitian and has completed training in nutrition, epidemiology, and methods of analyzing complex dietary and epidemiologic data. Her research interests include the relationships between diet and cancer, especially cancers of the breast, endometrium, and ovary. More specifically, she is interested in phytochemicals as dietary compounds affecting cancer risk and prognosis, and is further interested in the effect of genetic variation on these relationships. She has conducted several dietary intervention studies to investigate the role of dietary components in cancer or cancer related risk factors. She has also been involved in research that utilizes data reduction analytic methods such as principal components analysis. Finally, she is interested in the application of metabolomics and genomics to problems of diet in the etiology and prognosis of cancer and the role of the gut microbiome in cancer etiology.

She has conducted several clinical trials funded by the National Center for Complementary and Alternative Medicine and National Cancer Institute (NIH) studying the effects of flaxseed on breast cancer etiology and survival. Dr. McCann has recently investigated the role of modification of dietary glycemic load in expression of miRNAs related to cancer and energy metabolism and reported that a low glycemic diet may affect expression of several miRNAs related to energy metabolism and cancer processes. She is currently conducting a flaxseed intervention study in healthy African American and Caucasian postmenopausal women to investigate the interaction between the gut microbiome and genetic variation on changes in steroid hormone metabolism in response to the flaxseed intervention.

McCann has authored or co-authored more than 80 journal articles, abstracts, and book chapters, is a First Editor of Nutrition Research Reviews, and serves as an ad hoc reviewer for the American Journal of Clinical Nutrition, American Journal of Epidemiology, Cancer Causes and Control, and Cancer Epidemiology, Biomarkers and Prevention.

Dr. McCann is actively involved in the education of scientists at Roswell Park Cancer Institute. She has mentored numerous graduate students in the Interdisciplinary Sciences Masters degree program, and several masters and doctoral candidates in Epidemiology. She designed, and teaches annually, PTR 502 Analysis of Health Related Data.


Publications

Full Publications list on PubMed

McCann SE, Liu S, Wang D, Shen J, Hu Q, Hong C-C, Newman V, Zhao H. Reduction of dietary glycemic load modifies expression of miRNAs potentially associated with energy balance and cancer pathways in premenopausal women. Br J Nutr 2012 May 30:1-8 

Setiawan V, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, The Australian National Endometrial Cancer Study Group, Strom BL, Spurdle AB, Soslow RA, Shu X, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey Jr JV, Kolonel LN, Henderson BE, Hankingson SE, Hakansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courney KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL. Type I and II endometrial cancers: have they different risk factors? J Clin Oncol 2013 Jul10;31(20):2607-18

McCann SE, Edge SB, Hicks DG, Thompson LU, Morrison CD, Fetterly G, Andrews C, Clark K, Wilton J, Kulkarni S. A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers. Nutrition & Cancer 2014;66(4):566-75.

Williams AM, Bonner M, Ochs-Balcom HM, Hwang H, Morrison C, McCann SE. Dietary lignan intake and androgen receptor expression in breast tumors. Cancer Causes and Control 2015; Feb;26(2):311-7

McCann SE, Hays J, Baumgart CW, Weiss EH, Yao S, Ambrosone CB. Usual consumption of specific dairy foods is associated with breast cancer in the Roswell Park Cancer Institute Databank and BioRepository. Current Dev Nutr 2017;1(3)e000422 doi:https://doi.org/10.3945/cdn.117.000422