Dr. Sophia Balderman Sophia Balderman, MD

Sophia Balderman


Specializing In:

Myelodysplastic syndrome Acute myeloid leukemia

About Sophia Balderman


As a physician in the department of medicine at Roswell Park Comprehensive Cancer Center, I focus on caring for patients with high-risk malignant diseases that require bone marrow transplantation or other cellular therapies as part of their treatment. Providing excellent patient care in this setting requires a unique skill set and relies heavily on a collaborative approach by all members of the health care team. My clinical experience and the value I place on the practice of evidence-based medicine have enabled me to address highly relevant clinical questions, one of which evolved into my design and implementation of a phase II clinical trial which is currently open and accruing; the aim of this study is to determine whether utilizing peripheral blood stem cells rather than stem cells collected via bone marrow harvests is better in regard to maintaining or achieving remissions in patients with hematological diseases (mainly malignancies) with haploidentical HLA donors. I am also currently the site PI of a BMT CTN 1507 phase II study in which patients with sickle cell disease receive allogeneic transplants with haploidentical HLA donors; the goal of this trial is to determine whether patients with sickle cell disease receiving haploidentical transplants have similar outcomes to those who receive bone marrow stem cells from matched sibling (or matched unrelated) allogeneic donors. In addition to caring for transplant and cellular therapy patients, I have a clinical interest in benign hematology and hold a non-malignant hematology clinic weekly in which I see both internal consults as well as outpatient referrals; these interactions give me the opportunity to interact with other physicians including surgeons and primary care physicians in the community to provide comprehensive care for our mutual patients. I have additionally had a strong interest in particular in the diagnosis and treatment of myelodysplastic syndromes since my fellowship and continue to pursue lab-based projects in murine models of this disease, with a focus on the marrow microenvironment and how it might be therapeutically manipulated to improve outcomes.


Roswell Park Comprehensive Cancer Center
  • Assistant Professor of Oncology
Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
  • Department of Medicine


Education and Training:

  • 2008 - MD - Upstate Medical University, College of Medicine, Syracuse, NY


  • 2011 - Internal Medicine - University of Rochester, Strong Memorial Hospital, Rochester, NY


  • 2013 - Hematology - University of Rochester, Strong Memorial Hospital, Rochester, NY

Board Certification:

  • Internal Medicine
  • Hematology

Professional Memberships:

  • American Society of Hematology
  • American Society of Transplant and Cellular Therapy

Clinical Trials


Full Publications list on PubMed
  • Balderman SR, Li AJ, Hoffman CM, Frisch BJ, Goodman AN, LaMere MW, Georger MA, Evans AG, Liesveld JL, Becker MW, Calvi LM. Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome. Blood. 2016 Feb 4;127(5):616-25. doi: 10.1182/blood-2015-06-653113. Epub 2015 Dec 4. PMID: 26637787; PMCID: PMC4742549.
  • Balderman SR, Calvi LM. Biology of BM failure syndromes: role of microenvironment and niches. Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):71-6. doi: 10.1182/asheducation-2014.1.71. Epub 2014 Nov 18. PMID: 25696837; PMCID: PMC4419374.
  • Lichtman MA, Balderman SR. Unusual Manifestations of Essential Monoclonal Gammopathy. II. Simulation of the Insulin Autoimmune Syndrome. Rambam Maimonides Med J. 2015 Jul 30;6(3):e0027. doi: 10.5041/RMMJ.10212. PMID: 26241232; PMCID: PMC4524400.
  • Balderman SR, Lichtman MA. Unusual Manifestations of Monoclonal Gammopathy: I. Ocular Disease. Rambam Maimonides Med J. 2015 Jul 30;6(3):e0026. doi: 10.5041/RMMJ.10211. PMID: 26241228; PMCID: PMC4524399.
  • Balderman S, Lichtman MA. A history of the discovery of random x chromosome inactivation in the human female and its significance. Rambam Maimonides Med J. 2011 Jul 31;2(3):e0058. doi: 10.5041/RMMJ.10058. PMID: 23908816; PMCID: PMC3678792.

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