The Vector Development and Production Facility (VDPF) occupies 1331 sq. ft. of space on the 6th floor of the Gratwick Basic Science Building. Key to the Translational Immuno-Oncology Shared Resource (TIOSR), the VDPF generates clinical-grade vectors/reagents that allow the genetic engineering of a patient’s cells, boosting their ability to efficiently fight cancer. The facility follows current good manufacturing practices, manufacturing products that meet specific requirements for identity, strength, quality, and purity in the pharmaceutical field, ensuring that the generated viral vector product is suitable for clinical use and compliant with FDA guidelines. The facility manufactures gamma-retroviral and lentiviral vectors required by different investigators or sponsors.
Technology
- Tangential flow filtration and Diafiltration System (KMPI KROSFLO M.KROS and KLOSFLO R IIii)
- Automated Hollow Fiber Bioreactor System
- Isensix Alarm system
- ChemiDoc
- Synergy HTX Microplate absorbance reader
- PCR cycler instruments
- 6-foot biosafety cabinets
- Heracell incubators
- SORVALL centrifuges
- Liquid Nitrogen storage containers
- -80 C, -20 C freezers
- Inverted microscopes
Location
Roswell Park Comprehensive Cancer Center
Vector Development and Production Facility
Translational Immuno-Oncology Shared Resource (TIOSR)
Elm and Carlton Streets
Buffalo, New York 14263
Meet our team
Joanna Stanson, MS
Operations Director
Phone: 716-845-6580
Zongsheng Guo, PhD
Associate Director
Cindy Bonura, BS
Senior Research Associate
Bryan Pratt, MS
Laboratory Technician