Small Molecule Screening Shared Resource Compound Libraries and Equipment

Libraries

• Drug Discovery Libraries
• Bioactive Libraries 

Library Format

All libraries are available in both the 96- and 384-well format. Screening in the 384-well format is faster and less expensive, but some of the assays are incompatible with this high density format. Below is the image delineating the location of compounds and empty wells used for controls on 96- and 384-well plates.

Equipment

Liquid Handling Group

Equipment used for automated delivery of liquid reagents and the transfer of compounds from the library to the assay plates in multi-well format.

• JANUS, PerkinElmer
• Compact Automated Reagent Dispensers

Detection Group

• EnVision Excite, PerkinElmer
• S5 UV Analyzer by CTL Technology Ltd.

TC Complex

Dedicated tissue culture equipment simplifies the procedure of cell preparation for cell based readout systems and the plating of the cells in multiwell format.

Our tissue culture room is equipped with a laminar flow hood, CO2 incubators, water baths, and automatic multichannel pipetors.