Historical libraries are collections of pre-existing organic compounds from different chemical labs selected based on their “drug-likeness”, and collections of pharmacological, bioactive or natural compounds. These libraries can be used for drug discovery as well as for “proof of principle” and assay validation experiments.
The Small Molecule Screening Shared Resource owns two historical libraries of diverse drug-like molecules for drug discovery projects:
- EXPRESS-Pick™ by ChemBridge Corporation (San Diego, CA): a diverse library of 55,230 compounds. This library consists of organic molecules with molecular weight in a range of 250 – 550, dissolved in DMSO at concentration 5mg/ml or 10-20 mM.
- HitDiscover by Maybridge (Part of Thermo Fisher): 52160 compounds dissolved in DMSO at 10mM concentration.