The Roswell Park Hematologic Procurement Shared Resource (formerly known as the Leukemia Tissue Bank) provides researchers and investigators with appropriately procured and cryopreserved samples of bone marrow and peripheral blood cells, DNA, RNA, and serum/plasma samples from patients with hematological malignancies treated at our institute.
Presently, the HTF contains over 100,000 cryopreserved marrow and blood samples from patients with hematological malignancies dating from the present back to 1991 linked to a clinical database. The majority of samples are from patients with acute leukemia. Approximately 70,300 samples from 1,550 individuals with acute myeloid leukemia (AML) and 11,700 samples from 260 patients with acute lymphocytic leukemia (ALL) are currently stored in this shared resource. Samples from patients with myeloid malignancies, chronic leukemias, lymphoproliferative diseases, multiple myeloma, and other hematological disorders are also available.
Personnel include a physician-scientist director, a lab manager, two full-time research technician/technologists, and a clinical database manager. Staffing is available after hours and on weekends for sample procurement and processing. The shared resource also contracts with Clinical Research Services to procure and store correlative biological samples for patients being treated on numerous clinical trials throughout the Institute.
The square footage of the lab where primary patient samples are being processed is 488.16 ft. The core has ten large LN2 freezers, one small LN2 freezer, three -80° stand up freezers, three -20° stand up freezers and one fridge/freezer. All freezers are on the Rees system. The core also has one 6 ft hood, one coulter counter, two refrigerated centrifuges and one non-refrigerated. In addition, the Core has a water bath and micro-centrifuge.