The Nicotine and Tobacco Product Assessment Resource (NicoTAR) provides instrumentation and services to investigators requiring nicotine and tobacco product testing, biochemical verification of smoking status and assessment of tobacco smoke exposure.
Major instrumentation includes Waters Xevo TQ-XS Tandem Mass Spectrometer with ACQUITY UPLC I-Class liquid chromatography system, Agilent gas chromatograph (GC, 7890B) with an Agilent mass spectrometer (MS, 5977A), Agilent gas GC with quadrupole time-of-flight mass spectrometry (QTOF, 7250), a Agilent gas GC with a nitrogen-phosphorus detector (NPD) and a PerkinElmer PinAAcle atomic absorption spectrometer (AAS, 900z). This instrumentation is capable of a wide variety of nicotine and tobacco product testing and tobacco-specific biomarker assessment. Application examples include determination of nicotine, carcinogens, and flavorings in tobacco products and electronic cigarettes, as well as tobacco-specific biomarkers in biofluids.
NicoTAR data processing software includes Open Lab CDS, SPSS, GraphPad and Statistica. A variety of laboratory equipment is available for sample preparation and storage (e.g., smoking machines, electronic shisha smoker, puffing monitors, cigarette ventilation and pressure drop tester, cigarette paper porosity tester, air-liquid, etc.) In addition to the facility directors and technicians, Roswell Park provides additional staff who aid in facility maintenance and repair (mechanical, cryogenic, electronic, IT).