The Roswell Park Comprehensive Cancer Center/University at Buffalo Gene Modulation Services Shared Resource (formerly shRNA Resource) provides a centralized, cost-effective service that supports investigators interested in in vitro gene transfer using viral vector technologies. RPCI/UB researchers are provided with access to:
- shRNA libraries for human and mouse; either as single genes or in a whole-genome wide pooled format.
- CRISPRi or CRISPRa pooled libraries for loss of function or gain of function studies, respectively
- LentiORF libraries for gain-of-function experiments.
- Additional Core-provided vectors such as those for tracking (GFP, LacZ, RFP, luciferase,) for cell immortization (large T-ag and hTERT,) and for TET regulation.
Using the Resource
Investigators interested in Gene Modulation Services or Mycoplasma testing should contact:
The Gene Modulation Services Resource is located in the Center for Genetics and Pharmacology (CGP), Room L2-135. Hours of operation are weekdays, 8:30 a.m. - 4:30 p.m.