Gene Modulation Services Resource


The Roswell Park Comprehensive Cancer Center/University at Buffalo Gene Modulation Services Shared Resource (formerly shRNA Resource) provides a centralized, cost-effective service that supports investigators interested in in vitro gene transfer using viral vector technologies. RPCI/UB researchers are provided with access to:

  • shRNA libraries for human and mouse; either as single genes or in a whole-genome wide pooled format.
  • CRISPRi or CRISPRa pooled libraries for loss of function or gain of function studies, respectively
  • LentiORF libraries for gain-of-function experiments.
  • Additional Core-provided vectors such as those for tracking (GFP, LacZ, RFP, luciferase,) for cell immortization (large T-ag and hTERT,) and for TET regulation.


Irwin Gelman, PhD
For consultation and questions regarding experimental design, please contact Dr. Gelman.
Voice: 716-845-7681

Using the Resource

Investigators interested in Gene Modulation Services or Mycoplasma testing should contact:

Renae Holtz
Voice: 716-845-1585


The Gene Modulation Services Resource is located in the Center for Genetics and Pharmacology (CGP), Room L2-135. Hours of operation are weekdays, 8:30 a.m. - 4:30 p.m.