Gene Targeting and Transgenic Selected Publications

  • Akakura S, Bouchard R, Bshara W, Morrison C, Gelman IH. Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulation. Int J Cancer 2011; 129(8):2025-2031. PMCID: PMC3107938
  • Akakura S, Huang C, Nelson PJ, Foster B, Gelman, IH. Loss of the ssecks/gravin/akap12 gene results in prostate hyperplasia. Can Res 2008; 68(13):5096-5103. PMCID: PMC2839164
  • Akakura S, Nochajski P, Gao L, Sotomayor P, Matsui S, Gelman IH. Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle 2010; 9(23):4656-4665. PMCID: PMC3048035
  • Glenn ST, Jones CA, Pan L, Gross KW. In vivo analysis of key elements within the renin regulatory region. Physiol Genomics 2008; 35(3):243-253. PMCID: PMC2585016
  • Golding M, Magri LS, Zhang L, Lalone SA, Higgins MJ, Mann MRW. Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells. Development 2011; 138(17): 3667-3678. PMCID: PMC3152924
  • Jones MB, Nasirikenari M, Feng L, Migliore MT, Choi KS, Kazim L, Lau JT. Role for hepatic and circulatory ST6Gal-1 sialyltransferase in regulating myelopoiesis. J Biol Chem 2010; 285(32):25009-25017. PMCID: PMC2915736
  • Kunnev D, Rusiniak ME, Kudla A, Freeland A, Cady GK, Pruitt SC. DNA damage response and tumorigenesis in Mcm2-deficient mice. Oncogene 2010; 29(25): 3630–3638. PMCID: PMC2892019
  • Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster BA, Johnson CS, Rustum YM, Porter CW. Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol 2010;176(4):1629-1638. PMCID: PMC2843455
  • Oh R, Ho R, Gertesenstein M, Paderova J, Hsien J, Squire J, Higgins MJ, Nagy A, Lefebvre L. Epigenetic and phenotypic consequences of a site-specific truncation disrupting the imprinted domain on distal mouse chromosome 7. Mol Cell Biol 2008; 28(3):1092-1103. PMCID: PMC2223404
  • Oh-McGinnis R, Bogutz AB, Lee K, Higgins MJ, Lefebvre L. Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol 2010; 10:50. PMCID: PMC2881899
  • Pruitt SC, Freeland A, Kudla A. Cell cycle heterogeneity in the Small Intestinal Crypt and Maintenance of Genome Integrity. Stem Cells 2010 Jul; 28(7): 1250-1259. PMCID: PMC3232743
  • Rusiniak ME, Kunnev D, Freeland A, Cady GK, Pruitt SC. Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma. Oncogene 2012; 31(36):4034-4044. PMCID: PMC3309111
  • Shin JY, Fitzpatrick GV, Higgins MJ. Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J 2008; 27(1): 168-178. PMCID: PMC2206141
  • Song F, Mahmood S, Ghosh S, Liang P, Smiraglia DJ, Nagase H, Held WA. Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development Genomics 2009; 93(2):130-139. PMCID: PMC2658018
  • Sun H, Wang Y, Chinnam M, Zhang X, Hayward SW, Foster BA, Nikitin AY, Wills M, Goodrich DW. E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo. Proc Natl Acad Sci U S A 2011;108(2):704-709. PMCID: PMC3021049
  • Xiao H, Zhang X, Goodrich DW. Construction of a Dual Affinity Tagged Allele of the Rb1 Tumor Suppressor Gene in the Mouse. Genesis 2010; 48(2): 121-126. PMCID: PMC2819610
  • Chinnam M, Goodrich DW. RB1, development, and cancer. Curr Top Dev Biol 2011; 94: 129-169. PMID: 21295686, PMCID pending.