The Biomedical Research Informatics Shared Resource (BRISR) is a shared resource for non-interventional studies. The primary focus of the BRISR is to provide structured access to and use of real-time reliable clinical data for the advancement of non-interventional studies at Roswell Park. BRISR provides the infrastructure and processes to establish and monitor data standards, quality, integration, and distribution across Roswell Park to support research. The BRISR office develops tools and methods to streamline the collection, storage, processing, and distribution of data to researchers. In addition to improving access to and use of clinical data, the BRISR Office, as a liaison with bio-banks, supports annotation of bio-specimens with clinical data and facilitates the process for researchers to timely and accurately identify and determine the availability of required specimens. The BRISR Office supports the data needs of investigators for Non Human Subject Research. The BRISR provides the leadership and the resources necessary to meet data management needs for each specific research project.