Bioanalytics, Metabolomics & Pharmacokinetics (BMPK) Services and Fees

Services

The Bioanalytics, Metabolomics & Pharmacokinetics (BMPK) Shared Resource is available to assist investigators in the design of clinical studies which incorporate clinical pharmacology or pharmacokinetic/pharmacodynamic questions. BMPK also offers assistance with the development of new assay methodologies and PK/PD data analysis. Emphasis is placed on designing studies that optimize efficiency and scientific rigor. Investigators are encouraged to consult the BMPK Shared Resource as early as possible during the planning phases of project or grant development.

Drug/Metabolite & Small Molecule Analysis (LC/MS/MS, HPLC)

Assays available:

  • Androgens: Testosterone (0.00625 ng/mL); Dihydrotestosterone (0.0125 ng/mL); Androstenedione (0.00625 ng/mL); Dehydroepiandrosterone (DHEA, 0.200 ng/mL); Androsterone (0.200 ng/mL) (LC/MS/MS)
  • Antimetabolies: Gemcitabine and dFdU (HPLC; LC/MS/MS); Capecitabine (LC/MS/MS); 5FU (LC/MS/MS)
  • Taxanes: Docetaxel (LC/MS/MS); Paclitaxel (LC/MS/MS); IDN5390(LC/MS/MS)
  • Topoisomerase targeted agents: Irinotecan, SN-38, SN-38G (HPLC); Etoposide (HPLC)
  • Anthracyclines: Doxorubicin and Daunorubicin (HPLC)
  • Vitamin-D/metabolites (HPLC, LC/MS/MS)
  • Targeted Agents : Sunitinib and SU11262 (LC/MS/MS)
  • Polyamines and analogs: Difluoromethyl ornithine (HPLC), Putrescine, spermidine and spermine (HPLC); N1N11diethylnorspermine (HPLC)
  • Cytoprotective and chemopreventive agents: Mesna (HPLC), BNP7787 (HPLC) and thiols (cysteine, homocysteine and glutathione) (HPLC); N-Acetylcysteine (HPLC)
  • Others: Nilutamide (HPLC, UV), Thiols (HPLC, UV), Tryptophan and Kynurenine (UPLC), Novobiocin (UPLC), See Attachments Below

Elemental Analysis (Atomic Absorption)

Assays available:

  • Platinum based compounds:  oxaliplatin, cisplatin, carboplatin
  • Selenium based compounds:  Selenomethionine, methylselenocysteine
  • Gold

Fees

Pricing varies and is as unique as every experiment designed. Interaction is vital to achieve appropriate experiment design and outcome. As a Roswell Park Bioanalytics, Metabolomics & Pharmacokinetics (BMPK) client, we will arrange a one-on-one consultation with you, utilizing the individual expertise we bring to the table. Together, we will examine your experimental design, methods development needs, analysis, and result interpretation in order to best suits your demands.  We work closely with you at every turn to ensure you receive the most pertinent and reliable results possible.

Investigators submitting samples are required to fill out a . Samples will not be analyzed without an attached submission form. Investigators interested in the use of the shared resource should contact Joshua Prey, MS to discuss scheduling and shared resource procedures.

 

Joshua Prey, MS
Research Project Administrator, BMPK Shared Resource
Center for Genetics and Pharmacology, L1-318
Phone: 716-845-3313
Email: joshua.prey@roswellpark.org

AttachmentSize
PDF icon Serum Estrogens177.63 KB
PDF icon Plasma Nintedanib242.31 KB
PDF icon Plasma Enzalutamide186.34 KB
PDF icon Plasma Tivozanib520.68 KB