Bioanalytics, Metabolomics & Pharmacokinetic Equipment

Instrumentation

  • Applied Biosystems 5500 Qtrap/Triple quadropole LC/MS/MS
  • Thermo Scientific TSQ Quantum Ultra triple quadrupole ESI/APCI-LC/MS/MS
  • Thermo Scientific TSQ Vantage triple quadrupole ESI/APCI-LC/MS/MS
  • Applied Biosystems API 3000 triple quadrupole LC/MS/MS
  • Waters Ultra Performance Liquid Chromotagraphy System
  • Waters High Performance Liquid Chromatography System
  • Agilent  High Performance Liquid Chromatography System
  • Perkin Elmer AAnalyst 600 Graphite Furnace Atomic Absorption
  • Biotek Synergy Plate Reader providing fluorescence and UV detection
  • TomTec Quadra 4 Robotic Handling System

The Bioanalytics, Metabolomics & Pharmacokinetic (BMPK) Resource also is equipped with state of the art PK/PD modeling software including:

  • WinNonlin Professional – For non-compartmental analysis and compartmental modeling for PK and/or PK/PD data
  • ADAPT 5 and S ADAPT – For individual compartmental PK and PK/PD modeling
  • NONMEM – Non-linear mixed effect modeling software for population analysis to ascertain sources of variability in both pharmacokinetics and pharmacodynamics of a drug
  • WinPOPT – Used to provide information for PK and/or PK/PD sampling strategies
  • SAS 9.2 – Used to manage and clean databases, create graphics and tables of results